Gene mutation found to increase Mediterranean diet effectiveness"Lower risk of fatty liver disease"
Jul 18, 2024
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A research team led by Professor Lee Ji-won and Professor Kwon Yong-jin of Family Medicine at Severance Hospital in Yongin announced on the 18th that if a person who practices a Mediterranean diet with Theragen Health has a gene mutation in the blood sugar enzyme control protein, the risk of developing metabolic abnormalities-related fatty liver disease is reduced by 16%.
The results of the study were published in the international journal Journal of Intermediary Medicine.
Fatty liver is a disease in which fat accounts for more than 5% of liver weight, and it is found in about 30% of the population. Metabolic dysassociated fatty liver disease is associated with an increase in unhealthy westernized diets. Metabolic dys-associated fatty liver disease not only increases the risk of cardio-cerebrovascular disease, but can also develop into severe liver fibrosis, cirrhosis and liver cancer.
The Mediterranean diet is characterized by high consumption of vegetables, fruits, nuts, grains, olive oil, and fish, as well as low saturated fat consumption, and is an effective diet for preventing chronic diseases such as heart disease and diabetes and reducing mortality. These advantages can vary depending on the race.
The research team investigated how the Mediterranean diet affects metabolic abnormalities-related fatty liver disease in Koreans. In the study, a questionnaire (K-MEDAS) asking how much the research team practices the Mediterranean diet they developed themselves was used. The survey checks the number of olive oil, vegetables, and fruits, as well as the degree of fish and seafood consumption.
First, data from 33,133 Koreans over the age of 40 were analyzed using data from the Korean Genome Dynamics Survey Project (KoGES). According to the degree of Mediterranean diet practice, we divided them into groups with high and low Mediterranean diet compliance.
Statistical analysis revealed the significance of gene mutation (rs780094) of protein GCCR involved in glycemic regulatory enzyme glucokinase activity. Genotype humans who inherited rs780094 from their parents had an approximately 12% lower prevalence of metabolic abnormalities-associated fatty liver disease. When they complied with the Mediterranean diet intake, the prevalence was reduced to about 16%.
In the group with low Mediterranean diet compliance, there was no association between rs780094 and the occurrence of metabolic abnormalities-related fatty liver disease.
Professor Ji-Won Lee "The Korean rs780094 gene interacts with the Mediterranean diet and can regulate the risk of metabolic abnormalities-related fatty liver disease."It has been revealed that certain genes are important factors influencing the disease prevention effectiveness of eating habits"
On the other hand, this study was conducted with the support of the Agriculture, Food and Rural Affairs Technology Evaluation Institute's 'Customized Meal Management Solutions and Home Food Research and Development' and the Korea Research Foundation's 'Exploration of Treatment Candidates through Multi-Omics Exploration after Dietary Development/Intervention Optimized for Metabolic Abnormal-Related Fatty Liver Diseases'. Lee Jiwon again?Professor Kwon Yong-jin's research team is working on medical food development through various large-scale national policy tasks and is developing a personalized diet based on data evidence using big data.
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