Himchan Hospital "Injection of bone marrow aspiration concentrate into the intra-articular cavity, pain reduction, and function improvement effect" published in a famous academic journal
Jul 02, 2024
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Artificial joint surgery is the best and last treatment for end-stage degenerative arthritis, which is already painful because all cartilage is worn out, but research on treatments for mid-term knee arthritis aimed at slowing the progression of arthritis as much as possible continues. In particular, intra-articular injection of bone marrow aspiration concentrate was recognized as a new medical technology by the Ministry of Health and Welfare in July last year for its effectiveness in relieving pain and improving joint function in patients with knee arthritis.
The study, which was jointly conducted by Lee Soo-chan, CEO of Himchan Hospital, Baek Ji-hoon, Nam Chang-hyun, and Lee Dong-nyeong, an orthopedic surgeon, showed that after an average of 7.2 months, pain decreased by about 91%, knee joint scores improved by about 13%, and knee function scores by about 22%.
Effectiveness and Complications of Bone Marrow Aspirate Concentrate In Patients with Knee Osteoarthritis of Kellgren-Lawrence Grades II-III)' containing the findings of this study was published in the world-renowned SCIE-level international journal Medicine in June.
The first author, Baek Ji-hoon, Director of Himchan Hospital (Orthopedic Surgeon), "There have been previous short-term follow-up studies that have demonstrated the effectiveness of intra-articular injection treatment of bone marrow aspiration concentrate in pain relief and function improvement, but there have not been many studies on large-scale follow-up results of at least 6 months for effects and complications. In particular, this study can be significant in that it evaluates and defines the effectiveness of intra-articular injection therapy of bone marrow aspiration concentrate for mid-term knee arthritis as well as the possibility of potential complications at the site of collection or treatment. "
From August to October 2023, the research team followed 285 patients with knee arthritis (231 patients, female-172 patients, and male-59) who received intra-articular injection of bone marrow aspiration concentrate for about 6 to 8 months (average 7.2 months). The average age of the subjects was 64.2 years, of which 58 received bone marrow stem cell injection treatment in both knees.
As a result of the study, it was confirmed that the pain was noticeably reduced. The Visual Analog Scale (VAS), which represents the degree of pain, decreased significantly from 4.3 points before the procedure to 0.4 points after an average of 7.2 months after the procedure. The pain evaluation scale selects the intensity of pain felt by the patient from 0 to 10, which means that the intensity of pain increases as it goes to 10. It was also found to be effective in improving joint function after treatment. As a result of measuring knee joint scores (KSS) and knee and function scores (knee and function scores) that evaluate pain and joint function, they improved from 86.9 points before and after treatment to 98.1 points and 68.4 points to 83.3 points, respectively.
In particular, this study is drawing attention because it clearly defined complications after intra-articular injection treatment of bone marrow aspiration concentrate, which has not been well dealt with before. As a result of the study, hematoma, abnormal sensation, contact dermatitis, and superficial infection occurred at the collection site, and a total of 15 (5.3%) complications, including swelling and pain, were observed at the injection site, but all recovered normally after a certain period of time through natural or appropriate treatment. In particular, major complications such as infection at the collection site or iliac crest fracture did not occur.
Director Nam Chang-hyun, Director of Himchan Hospital (Orthopedic Surgeon), said "Recently, the number of cases of intra-articular injection of bone marrow aspiration concentrate to treat knee arthritis is increasing, and in fact, it is expected to be an effective treatment to slow down artificial joint surgery as much as possible through pain relief and function improvement. However, since potential complications or side effects cannot be completely excluded even if they are minor, close observation by a specialist is required for several days after the procedure after injection treatment, and it is important to establish a treatment plan through consultation with a specialist with extensive clinical experience and procedural know-how."
Meanwhile, Himchan Hospital is using a patented separator to more stably extract concentrated bone marrow aspirates containing large amounts of stem cells and growth factors. In addition, it is expected to increase the effectiveness by activating the movement of stem cells and growth factors contained in the concentrated bone marrow aspirate using a patented activation device called PROACT+, which was approved by the Ministry of Food and Drug Safety earlier this year in collaboration with the manufacturer.
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