"Low NK cell activity increases the risk of developing hypertension"
Jul 02, 2024
A joint research team at Chaum and Bundang Cha Hospital published a study result showing that NK cell activity and high blood pressure are related.
Chaum Lee Yoon-kyung (first author), Seo Eun-kyung and Oh Hyo-joo, and Bundang Cha Hospital Professor Kim Young-sang (communication author) and Ham Ji-hee analyzed the relationship between NK cell activity and high blood pressure in 1,453 adult men and women, and confirmed that lower NK cell activity increases the incidence of high blood pressure.
The research team divided NK cell activity into four groups and observed the relationship with hypertension for five years (average 2.13 years). As a result, the group with NK cells below 300 pg/mL had a 1.6-fold higher incidence of hypertension than the group with more than 1700 pg/mL.
NK cells are immune cells that detect and remove abnormal cells such as cancer cells or virus-infected cells by themselves, and the normal level is 500 pg/mL or higher. Until now, NK cell-related studies have confirmed the relationship with immunity and aging, but this is the first time to confirm the relationship with hypertension, a vascular disease.
Professor Lee Yun-kyung Chaum confirmed that NK cells, which play a role in controlling vascular inflammation, are involved as mechanisms that cause vascular endothelial damage and dysfunction in hypertensive patients"In various diseases, treatment to increase NK cell activity and increase immunity will become increasingly important."
Meanwhile, the results of this study were recently published in the International Journal of Immunology 'Frontiers in Immunology (IF:7.3)'.
Chaum Lee Yoon-kyung (first author), Seo Eun-kyung and Oh Hyo-joo, and Bundang Cha Hospital Professor Kim Young-sang (communication author) and Ham Ji-hee analyzed the relationship between NK cell activity and high blood pressure in 1,453 adult men and women, and confirmed that lower NK cell activity increases the incidence of high blood pressure.
The research team divided NK cell activity into four groups and observed the relationship with hypertension for five years (average 2.13 years). As a result, the group with NK cells below 300 pg/mL had a 1.6-fold higher incidence of hypertension than the group with more than 1700 pg/mL.
NK cells are immune cells that detect and remove abnormal cells such as cancer cells or virus-infected cells by themselves, and the normal level is 500 pg/mL or higher. Until now, NK cell-related studies have confirmed the relationship with immunity and aging, but this is the first time to confirm the relationship with hypertension, a vascular disease.
Professor Lee Yun-kyung Chaum confirmed that NK cells, which play a role in controlling vascular inflammation, are involved as mechanisms that cause vascular endothelial damage and dysfunction in hypertensive patients"In various diseases, treatment to increase NK cell activity and increase immunity will become increasingly important."
Meanwhile, the results of this study were recently published in the International Journal of Immunology 'Frontiers in Immunology (IF:7.3)'.
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