Narrowed 'Thigh Arteries', Intravascular Ultrasound Maximizes Treatment Effect
Jul 22, 2024
A way to improve the treatment outcome of the procedure to widen the narrowed femoral and artery has been developed.
A research team led by Koh Young-guk, Choi Dong-hoon, Ahn Cheol-min, and Lee Seung-joon of the Department of Cardiology at Severance Hospital announced on the 22nd that the rate of re-stenosis can be reduced by up to 13.7% when 'intravascular ultrasound' is combined with drug-coated balloon dilatation in the treatment of femoral and arterial stenosis.
The femoral artery, located in the thigh, is a blood vessel that transmits blood from the heart to the legs. If stenosis (narrowing) occurs in this artery due to adult disease or incorrect eating habits, pain in the calf can occur when walking, and in severe cases, the foot can be necrotic.
For the treatment, balloon dilatation, which inflates balloons by inserting them into blood vessels, or stents (metal mesh) were inserted, but there were frequent re-strainings, which narrowed blood vessels again shortly afterwards. In order to reduce the incidence of re-strain, a drug-coated balloon dilatation technique was developed by adding a special drug to the balloon. When a balloon is inflated, the drug on the balloon is delivered to the blood vessels, preventing it from narrowing again.
In general, when performing vasodilation, the target vascular structure is checked by angiography, in which a contrast agent is injected to photograph blood vessels. However, angiography has limitations in determining the exact size and shape of blood vessels.
Professor Ko Young-guk's research team used 'intravascular ultrasound' to overcome these limitations and maximize the therapeutic effect of drug coding balloon dilatation, and then analyzed the clinical results of the effect. As before, the study was divided into A group (118 people) using angiography and B group (119 people) using intravascular ultrasound and followed up for 12 months.
As a result of the study, it was confirmed that the degree of vascular expansion in group B, which combined intravascular ultrasound, was up to 1.51mm wider than that of group A, so the blood vessels targeted for treatment were more effectively expanded.
In addition, the primary patency rate, in which the treated blood vessels are maintained without narrowing again, was 83.8% in group B, higher than that in group A (70.1%), and the rate of survival without reoperation during the same period was 92.4% in group B and 83% in group A, which performed better in the group using intravascular ultrasound.
Professor Ko Young-guk explained, "When drug-coated balloon procedures were performed due to narrowing of the femur and artery passing through the thigh, using intravascular ultrasound to clearly identify the vascular structure was effective in improving treatment outcomes."This is the first study to reveal that intravascular ultrasound can improve drug-coated balloon performance in peripheral arterial interventions such as femoral and arterial dilatation procedures.'
The findings were published in the latest issue of the European Heart Journal (IF 39.3), a prominent international journal in the field of cardiovascular blood vessels.
A research team led by Koh Young-guk, Choi Dong-hoon, Ahn Cheol-min, and Lee Seung-joon of the Department of Cardiology at Severance Hospital announced on the 22nd that the rate of re-stenosis can be reduced by up to 13.7% when 'intravascular ultrasound' is combined with drug-coated balloon dilatation in the treatment of femoral and arterial stenosis.
The femoral artery, located in the thigh, is a blood vessel that transmits blood from the heart to the legs. If stenosis (narrowing) occurs in this artery due to adult disease or incorrect eating habits, pain in the calf can occur when walking, and in severe cases, the foot can be necrotic.
For the treatment, balloon dilatation, which inflates balloons by inserting them into blood vessels, or stents (metal mesh) were inserted, but there were frequent re-strainings, which narrowed blood vessels again shortly afterwards. In order to reduce the incidence of re-strain, a drug-coated balloon dilatation technique was developed by adding a special drug to the balloon. When a balloon is inflated, the drug on the balloon is delivered to the blood vessels, preventing it from narrowing again.
In general, when performing vasodilation, the target vascular structure is checked by angiography, in which a contrast agent is injected to photograph blood vessels. However, angiography has limitations in determining the exact size and shape of blood vessels.
Professor Ko Young-guk's research team used 'intravascular ultrasound' to overcome these limitations and maximize the therapeutic effect of drug coding balloon dilatation, and then analyzed the clinical results of the effect. As before, the study was divided into A group (118 people) using angiography and B group (119 people) using intravascular ultrasound and followed up for 12 months.
As a result of the study, it was confirmed that the degree of vascular expansion in group B, which combined intravascular ultrasound, was up to 1.51mm wider than that of group A, so the blood vessels targeted for treatment were more effectively expanded.
In addition, the primary patency rate, in which the treated blood vessels are maintained without narrowing again, was 83.8% in group B, higher than that in group A (70.1%), and the rate of survival without reoperation during the same period was 92.4% in group B and 83% in group A, which performed better in the group using intravascular ultrasound.
Professor Ko Young-guk explained, "When drug-coated balloon procedures were performed due to narrowing of the femur and artery passing through the thigh, using intravascular ultrasound to clearly identify the vascular structure was effective in improving treatment outcomes."This is the first study to reveal that intravascular ultrasound can improve drug-coated balloon performance in peripheral arterial interventions such as femoral and arterial dilatation procedures.'
The findings were published in the latest issue of the European Heart Journal (IF 39.3), a prominent international journal in the field of cardiovascular blood vessels.
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