Stroke-Inducing Vascular Stenosis, Real-Time Monitoring 'Fluorescence Sensor' Development
Jul 25, 2024
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Professor Park Bum-joon said, `This study opened a new way for the study of diseases such as vascular stenosis", he explained his significance. In recognition of its excellence, the research results were published in the July issue of the world-renowned journal 'Nature Communications'.
Cardiovascular disease is one of the deadly diseases that kills millions of people every year. Double vascular stenosis is caused by the accumulation of plaque inside the arteries, which puts great pressure on the narrowed blood vessel wall due to the accumulated plaque in the blood vessels. This pressure can rupture or drop plaque, causing serious problems such as stroke. To prevent this, various studies have been conducted to monitor the pressure inside blood vessels in real time so far, but there have been no cases where pressure has been visualized and measured in an environment similar to the actual blood vessels.
Professor Park Bum-joon's research team is poly using the co-flow microfluidic methodIacetylene (PDA) particles were fabricated. The particles change color and emit light when subjected to external stimuli, and the research team used this characteristic to analyze how mechanical pressure acts in a blood vessel-like environment using a fluorescence microscope. We measured how the mechanical stress caused the color change of the particles by fluid flow, and quantified the results.
The research results are expected to be used in various areas that are difficult to access in the human body because mechanical stress can be effectively measured and visualized by simulating problems in specific body parts.
Professor Beom-Jun Park explained that "We will provide important data for the prevention and treatment of cardiovascular and neurological diseases in the future." The research team plans to conduct further research to achieve more accurate results in various environments by increasing particle sensitivity.
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