Discovery of new markers for cancer distant metastasis; The development of diagnostic tools and treatments is expected
Aug 12, 2024
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Splicing is one of the processes that take place in the process of DNA being converted into RNA to make a protein. Selective splicing is a process that allows a single gene to make several types of proteins. Even the same gene can be spliced in various ways to produce slightly different proteins. This difference allows the same gene to affect different diseases. This process has recently received great attention in the field of genomic research because it provides very important clues for finding genetic markers associated with genetic diseases.
The research team found that selective splicing modification of the RPS24 gene, which plays an important role in cell protein synthesis, plays an important role in cancer metastasis. We found that four types of selective splicing variants occur in the RPS24 gene, confirming that these variants exhibit different expression patterns in normal and cancer tissues.
The research team analyzed the expression pattern of selective splicing variants of 23 major cancers and found that the expression rate varies greatly for each type of cancer. This suggests that selective splicing modification of the RPS24 gene may be a useful marker for cancer diagnosis and prognosis judgment. In addition, we found that selective splicing modification plays a role in promoting epithelial mesenchymal transition (EMT, which means that epithelial cells change into infiltrating and motile mesenchymal cells, and occurs when metastatic cancer or fibrosis occurs) during cancer metastasis.
Existing studies have known about the possibility that selective splicing strains may be associated with cancer, but accurate analysis was difficult due to very fine strains (three base differences). In the present study, we successfully detected selective splicing modifications of the RPS24 gene using a novel method called fragment analysis. This is an important achievement that presents new possibilities for the field of selective splicing research.
Professor Jiyeon Park said "This study will open up new possibilities for cancer research and treatment"This study is expected to actively promote the development of new cancer diagnostic tools and treatments based on selective splicing modifications of the RPS24 gene"
Professor Jeong Yeon-jun "The results of this study are expected to provide an important basis for developing new strategies for cancer diagnosis and treatment, and research to identify the biological functions of selective splicing modifications will provide a clearer understanding of the mechanism of cancer development and progression." he said.
The study was carried out with infrastructure support from the Catholic Medical Center's Basic Medicine Promotion Team and was published in the famous journal 『Scientific Reports』.
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