Korea University Guro Hospital Develops Endocardial Vascular Treatment Technology Using Light
Aug 08, 2024
Domestic researchers have developed a new source technology that can use light to diagnose cardiac arrest-induced arteriosclerosis simultaneously and target it. This technology uses an intravascular catheter to accurately identify dangerous areas and treat them by shining light on them.
The convergence research team consisting of Kim Jin-won, a professor at Korea University Guro Hospital Cardiovascular Center, Yoo Hong-ki, a professor of mechanical engineering at KAIST, and Park Kyung-soon, a professor of system biotechnology at Chung-Ang University, combined the carrier targeting specific receptors of arteriosclerotic macrophages and the vast body, administered to rabbit blood vessels, and irradiated light using an intravascular catheter, successfully treating inflammatory high-risk arteriosclerotic plaque simultaneously with real-time precise imaging diagnosis.
The therapeutic effect was tracked and verified in vivo through an intravascular molecular imaging catheter, and the main mechanism of the therapeutic effect was the detection and removal of apoptotic cells by photoactivation, cholesterol leakage to relieve inflammation, and to induce collagen tissue increase.
Professor Kim Jin-won, the lead author of the study, said "This study not only showed that light-based arteriosclerosis treatment and targeted precision imaging diagnosis using intravascular catheters are possible at the same time, but also showed new possibilities in the field of cardiovascular diagnostic treatment by revealing the treatment mechanism in detail.""If this technology is commercialized, it is expected that it will overcome the limitations of conventional stent treatment with the risk of foreign substances remaining."The significance of the study was revealed.
The findings were published online in Circulation Research (5-year Journal Impact Factor 20.3), the most prominent journal of basic cardiovascular research, and will be officially published in the latest issue on August 15. This study was conducted with the support of the Korea Research Foundation.
The convergence research team consisting of Kim Jin-won, a professor at Korea University Guro Hospital Cardiovascular Center, Yoo Hong-ki, a professor of mechanical engineering at KAIST, and Park Kyung-soon, a professor of system biotechnology at Chung-Ang University, combined the carrier targeting specific receptors of arteriosclerotic macrophages and the vast body, administered to rabbit blood vessels, and irradiated light using an intravascular catheter, successfully treating inflammatory high-risk arteriosclerotic plaque simultaneously with real-time precise imaging diagnosis.
The therapeutic effect was tracked and verified in vivo through an intravascular molecular imaging catheter, and the main mechanism of the therapeutic effect was the detection and removal of apoptotic cells by photoactivation, cholesterol leakage to relieve inflammation, and to induce collagen tissue increase.
Professor Kim Jin-won, the lead author of the study, said "This study not only showed that light-based arteriosclerosis treatment and targeted precision imaging diagnosis using intravascular catheters are possible at the same time, but also showed new possibilities in the field of cardiovascular diagnostic treatment by revealing the treatment mechanism in detail.""If this technology is commercialized, it is expected that it will overcome the limitations of conventional stent treatment with the risk of foreign substances remaining."The significance of the study was revealed.
The findings were published online in Circulation Research (5-year Journal Impact Factor 20.3), the most prominent journal of basic cardiovascular research, and will be officially published in the latest issue on August 15. This study was conducted with the support of the Korea Research Foundation.
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