"Patients of pulmonary tuberculosis with diabetes complications, 2.5 times higher risk of death"
Aug 15, 2024
An international academic journal has published a study showing that pulmonary tuberculosis patients with diabetes complications have poor treatment and a high risk of death.
This is the first large-scale study to analyze data on pulmonary tuberculosis patients in Korea.
Tuberculosis patients with diabetes are known to have a high risk of treatment failure. However, data on the effect of diabetes status on treatment outcomes are scarce and there have been no large-scale studies with domestic patients.
A team of professors Min Jin-soo (corresponding author) of the Department of Respiratory Medicine at Seoul St. Mary's Hospital of Catholic University and Kim Kyung-hoon (first author) of the Department of Respiratory Medicine at Incheon St. Mary's Hospital analyzed Korean tuberculosis cohort data to determine the effect of diabetes and blood sugar control on the treatment of tuberculosis patients in Korea.
We also analyzed patients with diabetes and complications among patients with pulmonary tuberculosis enrolled in the multicenter prospective TB cohort study database, and assessed their impact on treatment outcomes by multivariate logistic regression analysis. The team also performed an additional analysis to assess the association of outcomes with various diabetes conditions (untreated and uncontrolled diabetes, pre-diabetes).
As a result, the likelihood of poor pulmonary TB treatment outcomes was 1.6 times higher in patients with diabetes and 1.8 times higher in patients with diabetes complications compared to patients with no diabetes.
In addition, the risk of death in patients with pulmonary tuberculosis with diabetes complications was 2.5 times higher, and the risk of death in patients with pulmonary tuberculosis who had diabetes but had not received treatment was 4.7 times higher. This means that if diabetes is not properly treated, there is a higher risk of death, discontinuation of treatment, and failure of treatment during pulmonary tuberculosis treatment.
Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis. When a tuberculosis patient coughs, tuberculosis bacteria discharged into the air are temporarily floating in the air, which enter the lungs and cause infection when people around them breathe. Although it is known to occur mainly in developing countries, Korea still has the second-largest incidence of tuberculosis and the fourth-largest mortality rate among OECD member countries as of 2023.
Cough, the most common symptom of tuberculosis, has also been observed in colds, asthma, and bronchitis, making it difficult to distinguish by symptoms alone. A cough that lasts more than two weeks may not be a simple cold, so hospital treatment is necessary. In Korea, if it is determined that 'pulmonary tuberculosis is suspected' through a national health examination, you can receive free treatment and examination at a nearby medical institution. Most tuberculosis is treated only by taking drugs, and out-of-pocket expenses related to tuberculosis treatment can be supported by health insurance.
Professor Min Jin-soo said, "It is necessary to examine diabetes at the beginning of tuberculosis diagnosis and during treatment, and it is important to identify blood sugar control in diabetic patients when diagnosing tuberculosis to combat tuberculosis, while active diabetes management is performed to increase the cure rate of tuberculosis treatment.", explaining the significance of the study.
This paper was published in the recent issue of the official international journal 'Respirology' of the Asia-Pacific Respiratory Society.
Meanwhile, Professor Min Jin-soo has been selected as a policy research service project of the National Institute of Health, 'Tuberculosis cohort research', and has been operating 'COSMOTB (CohOrt Study of pulmonary TuBerculosis)' as a lead researcher since 2019.
This is the first large-scale study to analyze data on pulmonary tuberculosis patients in Korea.
Tuberculosis patients with diabetes are known to have a high risk of treatment failure. However, data on the effect of diabetes status on treatment outcomes are scarce and there have been no large-scale studies with domestic patients.
A team of professors Min Jin-soo (corresponding author) of the Department of Respiratory Medicine at Seoul St. Mary's Hospital of Catholic University and Kim Kyung-hoon (first author) of the Department of Respiratory Medicine at Incheon St. Mary's Hospital analyzed Korean tuberculosis cohort data to determine the effect of diabetes and blood sugar control on the treatment of tuberculosis patients in Korea.
We also analyzed patients with diabetes and complications among patients with pulmonary tuberculosis enrolled in the multicenter prospective TB cohort study database, and assessed their impact on treatment outcomes by multivariate logistic regression analysis. The team also performed an additional analysis to assess the association of outcomes with various diabetes conditions (untreated and uncontrolled diabetes, pre-diabetes).
As a result, the likelihood of poor pulmonary TB treatment outcomes was 1.6 times higher in patients with diabetes and 1.8 times higher in patients with diabetes complications compared to patients with no diabetes.
In addition, the risk of death in patients with pulmonary tuberculosis with diabetes complications was 2.5 times higher, and the risk of death in patients with pulmonary tuberculosis who had diabetes but had not received treatment was 4.7 times higher. This means that if diabetes is not properly treated, there is a higher risk of death, discontinuation of treatment, and failure of treatment during pulmonary tuberculosis treatment.
Tuberculosis is an airborne infectious disease caused by Mycobacterium tuberculosis. When a tuberculosis patient coughs, tuberculosis bacteria discharged into the air are temporarily floating in the air, which enter the lungs and cause infection when people around them breathe. Although it is known to occur mainly in developing countries, Korea still has the second-largest incidence of tuberculosis and the fourth-largest mortality rate among OECD member countries as of 2023.
Cough, the most common symptom of tuberculosis, has also been observed in colds, asthma, and bronchitis, making it difficult to distinguish by symptoms alone. A cough that lasts more than two weeks may not be a simple cold, so hospital treatment is necessary. In Korea, if it is determined that 'pulmonary tuberculosis is suspected' through a national health examination, you can receive free treatment and examination at a nearby medical institution. Most tuberculosis is treated only by taking drugs, and out-of-pocket expenses related to tuberculosis treatment can be supported by health insurance.
Professor Min Jin-soo said, "It is necessary to examine diabetes at the beginning of tuberculosis diagnosis and during treatment, and it is important to identify blood sugar control in diabetic patients when diagnosing tuberculosis to combat tuberculosis, while active diabetes management is performed to increase the cure rate of tuberculosis treatment.", explaining the significance of the study.
This paper was published in the recent issue of the official international journal 'Respirology' of the Asia-Pacific Respiratory Society.
Meanwhile, Professor Min Jin-soo has been selected as a policy research service project of the National Institute of Health, 'Tuberculosis cohort research', and has been operating 'COSMOTB (CohOrt Study of pulmonary TuBerculosis)' as a lead researcher since 2019.
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