Use of adipose stem cells to minimize side effects of breast cancer reconstruction prosthesis
Aug 21, 2024
In the treatment of breast cancer, breast reconstruction using prosthesis after mastectomy is the most common reconstruction method, but several side effects and risks can occur after surgery.
In particular, if chemotherapy is required after surgery, there is an increased risk of complications such as spherical construction (球型拘縮) and tissue necrosis that thicken surrounding tissues during the treatment process, and there may be situations in which changes in reconstruction methods and treatment processes must be considered, and breast reconstruction should be abandoned in severe cases.
Meanwhile, a research team led by Kang Shin-hyuk, a professor of plastic surgery at Chung-Ang University Hospital, recently published a research paper on how to use fat-derived stem cells to suppress side effects caused by prosthetics used for breast reconstruction (Tumor Necrosis Factor-a-Treated Human Adipose-Derived Stem Cells Inheritance Radiation Tolerance and Alleviate In Vivo Radiation-Independent Capsular Contract).
Professor Kang Shin-hyuk's research team succeeded in enhancing the effectiveness of tissue regeneration by cultivating stem cells separated from the patient's adipose tissue to strengthen the function of secretion of growth factors.
In animal experiments conducted by stably applying stem cells with enhanced growth factor secretion function to the surface of the prosthesis, it was demonstrated that it can suppress spherical construction (球型拘縮, Capsular Contracture, a side effect of radiation treatment performed after breast cancer surgery).
Until now, breast cancer patients have been at risk of reoperation due to side effects such as spherical construction and tissue necrosis caused by chemotherapy after breast cancer reconstruction surgery, as well as extreme pain, discomfort, and chronic injuries that do not heal, and the results of this study are raising expectations for new treatments to minimize these side effects.
Professor Kang Shin-hyuk said, `It has increased the effectiveness of tissue regeneration by separating and culturing fat-derived stem cells using adipose tissue, which is discarded after various surgeries, and selectively increasing the secretion function of specific growth factors suitable for treating tissue damage caused by anticancer radiation.'
Based on the results of this study, it is predicted that fat-derived stem cells will be used in various research fields and that various treatment purposes can be appliedWe hope to help develop effective treatments for patients suffering from defects and damage to body tissue.
Meanwhile, Professor Kang Shin-hyuk's research will be published in the latest issue of the world-renowned SCIE-level journal 『Journal of Advanced Research』, which recorded an impact factor (IF).
In particular, if chemotherapy is required after surgery, there is an increased risk of complications such as spherical construction (球型拘縮) and tissue necrosis that thicken surrounding tissues during the treatment process, and there may be situations in which changes in reconstruction methods and treatment processes must be considered, and breast reconstruction should be abandoned in severe cases.
Meanwhile, a research team led by Kang Shin-hyuk, a professor of plastic surgery at Chung-Ang University Hospital, recently published a research paper on how to use fat-derived stem cells to suppress side effects caused by prosthetics used for breast reconstruction (Tumor Necrosis Factor-a-Treated Human Adipose-Derived Stem Cells Inheritance Radiation Tolerance and Alleviate In Vivo Radiation-Independent Capsular Contract).
Professor Kang Shin-hyuk's research team succeeded in enhancing the effectiveness of tissue regeneration by cultivating stem cells separated from the patient's adipose tissue to strengthen the function of secretion of growth factors.
In animal experiments conducted by stably applying stem cells with enhanced growth factor secretion function to the surface of the prosthesis, it was demonstrated that it can suppress spherical construction (球型拘縮, Capsular Contracture, a side effect of radiation treatment performed after breast cancer surgery).
Until now, breast cancer patients have been at risk of reoperation due to side effects such as spherical construction and tissue necrosis caused by chemotherapy after breast cancer reconstruction surgery, as well as extreme pain, discomfort, and chronic injuries that do not heal, and the results of this study are raising expectations for new treatments to minimize these side effects.
Professor Kang Shin-hyuk said, `It has increased the effectiveness of tissue regeneration by separating and culturing fat-derived stem cells using adipose tissue, which is discarded after various surgeries, and selectively increasing the secretion function of specific growth factors suitable for treating tissue damage caused by anticancer radiation.'
Based on the results of this study, it is predicted that fat-derived stem cells will be used in various research fields and that various treatment purposes can be appliedWe hope to help develop effective treatments for patients suffering from defects and damage to body tissue.
Meanwhile, Professor Kang Shin-hyuk's research will be published in the latest issue of the world-renowned SCIE-level journal 『Journal of Advanced Research』, which recorded an impact factor (IF).
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