World's First Identification of New Gene Function to Progress Chronic Myeloid Leukemia
Aug 15, 2024
In a gene related to the occurrence and progression of chronic myeloid leukemia, a new function of 'recovery of damaged DNA' was discovered. In the future, it is expected that the development of treatments to control this will be possible.
The study was revealed for the first time in the world in a five-year collaboration between Kim Dong-wook, a professor of blood medicine at Eulji University Hospital in Uijeongbu, Kim Hong-tae, a professor of life sciences at Ulsan Institute of Science and Technology, and Kim Jae-jin, a professor of life sciences at Hallym University.
The joint research team analyzed the REXO5 (RNA Exonuclease 5) protein extracted from samples of 60 acute chronic myeloid leukemia (CML) patients and identified how it affects DNA damage and whether it causes leukemia.
Studies have shown that depletion of REXO5 protein increases the instability of the genome by a ring-shaped R-LOOP structure in which RNA adheres to damaged DNA. In addition, it was observed that not only S-giga involved in replication decreased compared to normal cells, but also cell growth was greatly inhibited. This was because REXO5 had the ability to repair DNA damage.
In other words, the REXO5 protein bound to the RNA strand of the R-loop and moved to the DNA damage site, and then the RNA strand of the R-loop was degraded through the nuclease site, and the DNA damage genome was restored as the R-loop was deconstructed. In addition, depletion of REXO5 protein inhibited cell growth. It has been revealed that REXO5 plays an important function in promoting abnormal chronic myelogenous leukemia cell growth.
The results of this study discovered a new function of REXO5 protein, which is known to be involved in RNA processing, and the world's first study to determine the link between leukemia development and DNA damage response.
Professor Kim Dong-wook of Uijeongbu Eoul University Hospital said, `The results of this study suggest the possibility of developing a new treatment that regulates REXO5 protein, and it is expected to slow down or suppress acute progression from chronic period.'
Professor Kim Hong-tae of Ulsan Institute of Science and Technology said, `This study has revealed in detail the molecular function of REXO5 newly discovered in blood cancer." It provided the basis for leukemia control strategies characterized by DNA damage responses.'
The study was published online on the 30th of last month in the world's prestigious international academic journal 'Leukemia (IF 12.8 (Top 5.7 percent).
The study was revealed for the first time in the world in a five-year collaboration between Kim Dong-wook, a professor of blood medicine at Eulji University Hospital in Uijeongbu, Kim Hong-tae, a professor of life sciences at Ulsan Institute of Science and Technology, and Kim Jae-jin, a professor of life sciences at Hallym University.
The joint research team analyzed the REXO5 (RNA Exonuclease 5) protein extracted from samples of 60 acute chronic myeloid leukemia (CML) patients and identified how it affects DNA damage and whether it causes leukemia.
Studies have shown that depletion of REXO5 protein increases the instability of the genome by a ring-shaped R-LOOP structure in which RNA adheres to damaged DNA. In addition, it was observed that not only S-giga involved in replication decreased compared to normal cells, but also cell growth was greatly inhibited. This was because REXO5 had the ability to repair DNA damage.
In other words, the REXO5 protein bound to the RNA strand of the R-loop and moved to the DNA damage site, and then the RNA strand of the R-loop was degraded through the nuclease site, and the DNA damage genome was restored as the R-loop was deconstructed. In addition, depletion of REXO5 protein inhibited cell growth. It has been revealed that REXO5 plays an important function in promoting abnormal chronic myelogenous leukemia cell growth.
The results of this study discovered a new function of REXO5 protein, which is known to be involved in RNA processing, and the world's first study to determine the link between leukemia development and DNA damage response.
Professor Kim Dong-wook of Uijeongbu Eoul University Hospital said, `The results of this study suggest the possibility of developing a new treatment that regulates REXO5 protein, and it is expected to slow down or suppress acute progression from chronic period.'
Professor Kim Hong-tae of Ulsan Institute of Science and Technology said, `This study has revealed in detail the molecular function of REXO5 newly discovered in blood cancer." It provided the basis for leukemia control strategies characterized by DNA damage responses.'
The study was published online on the 30th of last month in the world's prestigious international academic journal 'Leukemia (IF 12.8 (Top 5.7 percent).
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