"Alzheimer's Gene Old Man, High Protein Intake Increases Memory by 40%"
Sep 24, 2024
Alzheimer's disease is one of the most common neurodegenerative diseases in the elderly, making daily life difficult due to the deterioration of various cognitive functions, including memory. So far, there is no treatment to return the damaged brain to normal other than symptoms improvement drugs for Alzheimer's disease, which emphasizes the importance of prevention through lifestyle improvement rather than treatment. Against this background, a study found that the more protein consumed, the better the illustration memory, a cognitive function related to Alzheimer's disease in the elderly.
The research team led by Prof. Kim Ji-wook (corresponding author), Prof. Geum Moo-sung (first author), Prof. Seo Kook-hee and Choi Young-min, and Prof. Kim Hyun-soo of the Department of Diagnostic Laboratory Medicine at Hallym University Dongtan Sacred Heart Hospital has confirmed this in the study of 「Protein intake and illustration memory: the regulatory role of the apolipoprotein E4 genotype」. The paper was published in the August issue of the international academic journal 'Alzheimer's Research & Therapy (number of identified papers: 7.9)'.
The research team investigated the association between protein intake and Alzheimer's disease-related cognitive decline in the elderly, especially illustrated memory, in 196 people aged 65 to 90 who participated in a cohort study on Alzheimer's at Hallym University Dongtan Heart Hospital. Of these, 113 had normal cognitive function, and 83 had mild cognitive impairment. Illustrated memory is a memory in the context of time and space among the types of memories, the ability to store and recall information, and damage occurs mainly in the early stages of Alzheimer's disease.
First, the classification of protein intake is a Mini-Nutritional Assessment method that evaluates the nutritional status of the elderly, and experienced researchers evaluated the participants' food intake for three months through interviews. Protein intake was classified as low, medium, and high based on dairy (milk, cheese, yogurt), legumes, eggs, meat, fish, and poultry intake.
In addition to cognitive function evaluation, blood vessel disease, overall physical activity, annual income, nutritional bio-indicators, blood tests, and Alzheimer's disease-related genetic tests were conducted to control various influencing variables.
As a result, the overall cognitive function score of the high protein intake group was 83, which was 24% higher than the cognitive function score of 67 of the low protein intake group. In particular, the illustrated memory score was 27% higher in the high protein intake group than the low protein group score of 34. Even when the influencing variables were corrected, the overall cognitive function and illustration memory were about 20% higher in the high protein intake group than in the low protein intake group. However, there were no significant differences between groups in non-memory cognitive function (language ability, execution function, space-time ability, and attention).
In addition, interaction analysis found a significant interaction between protein intake and the Alzheimer's disease gene, apolipoprotein E4 (APOE4), indicating that APOE4 regulates the relationship between protein intake and illustrated memory. Notably, in the presence of APOE4, the overall cognitive function and illustration memory of the high protein intake group were approximately 40% higher than those of the low protein intake group. This was analyzed to be due to the effect of APOE4 on the interaction between proteins and metabolic activities in the human body.
Professor Geum Moo-sung said, `This study confirmed that the more protein we consume, the better the illustration memory of the elderly"In the presence of genetic predisposition to Alzheimer's disease, protein intake may be particularly important for maintaining cognitive function."
Professor Kim Jiwook added "Enough protein intake promotes neuroplasticity, which is important for memory and learning, and positively influences the regulation of neurotrophic factors that play an important role in maintaining cognitive health"High protein intake seems to be able to offset these negative effects by interacting with the lipid metabolism and amyloid beta deposition mechanisms of the APOE4 gene, which are known to be directly associated with Alzheimer's disease and related cognitive decline"
Professor Kim also suggested clinically important implications that a protein-centered diet could have a positive impact on cognitive health in the elderly who are at high risk for Alzheimer's disease through the results of this study""Protein intake in the elderly can play an important role in preventing cognitive decline, and further research needs to clarify this."," he stressed.
Meanwhile, Hallym University Dongtan Sacred Heart Hospital has been conducting a cohort study on Alzheimer's disease since 2020 and is drawing meaningful results from lifestyle improvements such as healthy eating habits and high-intensity walking to prevent Alzheimer's disease.
The research team led by Prof. Kim Ji-wook (corresponding author), Prof. Geum Moo-sung (first author), Prof. Seo Kook-hee and Choi Young-min, and Prof. Kim Hyun-soo of the Department of Diagnostic Laboratory Medicine at Hallym University Dongtan Sacred Heart Hospital has confirmed this in the study of 「Protein intake and illustration memory: the regulatory role of the apolipoprotein E4 genotype」. The paper was published in the August issue of the international academic journal 'Alzheimer's Research & Therapy (number of identified papers: 7.9)'.
The research team investigated the association between protein intake and Alzheimer's disease-related cognitive decline in the elderly, especially illustrated memory, in 196 people aged 65 to 90 who participated in a cohort study on Alzheimer's at Hallym University Dongtan Heart Hospital. Of these, 113 had normal cognitive function, and 83 had mild cognitive impairment. Illustrated memory is a memory in the context of time and space among the types of memories, the ability to store and recall information, and damage occurs mainly in the early stages of Alzheimer's disease.
First, the classification of protein intake is a Mini-Nutritional Assessment method that evaluates the nutritional status of the elderly, and experienced researchers evaluated the participants' food intake for three months through interviews. Protein intake was classified as low, medium, and high based on dairy (milk, cheese, yogurt), legumes, eggs, meat, fish, and poultry intake.
In addition to cognitive function evaluation, blood vessel disease, overall physical activity, annual income, nutritional bio-indicators, blood tests, and Alzheimer's disease-related genetic tests were conducted to control various influencing variables.
As a result, the overall cognitive function score of the high protein intake group was 83, which was 24% higher than the cognitive function score of 67 of the low protein intake group. In particular, the illustrated memory score was 27% higher in the high protein intake group than the low protein group score of 34. Even when the influencing variables were corrected, the overall cognitive function and illustration memory were about 20% higher in the high protein intake group than in the low protein intake group. However, there were no significant differences between groups in non-memory cognitive function (language ability, execution function, space-time ability, and attention).
In addition, interaction analysis found a significant interaction between protein intake and the Alzheimer's disease gene, apolipoprotein E4 (APOE4), indicating that APOE4 regulates the relationship between protein intake and illustrated memory. Notably, in the presence of APOE4, the overall cognitive function and illustration memory of the high protein intake group were approximately 40% higher than those of the low protein intake group. This was analyzed to be due to the effect of APOE4 on the interaction between proteins and metabolic activities in the human body.
Professor Geum Moo-sung said, `This study confirmed that the more protein we consume, the better the illustration memory of the elderly"In the presence of genetic predisposition to Alzheimer's disease, protein intake may be particularly important for maintaining cognitive function."
Professor Kim Jiwook added "Enough protein intake promotes neuroplasticity, which is important for memory and learning, and positively influences the regulation of neurotrophic factors that play an important role in maintaining cognitive health"High protein intake seems to be able to offset these negative effects by interacting with the lipid metabolism and amyloid beta deposition mechanisms of the APOE4 gene, which are known to be directly associated with Alzheimer's disease and related cognitive decline"
Professor Kim also suggested clinically important implications that a protein-centered diet could have a positive impact on cognitive health in the elderly who are at high risk for Alzheimer's disease through the results of this study""Protein intake in the elderly can play an important role in preventing cognitive decline, and further research needs to clarify this."," he stressed.
Meanwhile, Hallym University Dongtan Sacred Heart Hospital has been conducting a cohort study on Alzheimer's disease since 2020 and is drawing meaningful results from lifestyle improvements such as healthy eating habits and high-intensity walking to prevent Alzheimer's disease.
|
bellho@sportschosun.com
