'Young people in their 20s and 30s with fatty liver, 55% higher risk of acute cardiac arrest'
Sep 26, 2024
Non-alcoholic fatty liver disease (MASLD) is a common disease that occurs in about 25% of the population.
Non-alcoholic fatty liver is known to be associated with cardiovascular disease or death as well as liver.
However, there were no established risk factors for acute cardiac arrest in young adults, so research was needed.
In the meantime, Choi Jong-il, a professor of circulatory medicine at Korea University's Anam Hospital (Cho Jong-il, Professor Chung Ju-hee, Professor Lim Sun-young, and Professor Han Kyung-do of the Department of Information Statistics Insurance and Mathematics at Soongsil University), recently conducted a study to confirm that young adults in their 20s and 30s are at increased risk of acute cardiac arrest in the presence of fatty liver.
The research team analyzed data from adults aged 20 to 39 who were screened between 2009 and 2012 through the National Health Insurance Corporation's National Examination Database. The fatty liver index was calculated through BMI, waist circumference, GGT, and triglyceride levels to determine the presence or absence of fatty liver.
Metabolic fatty liver disease is expected to be normal when the fatty liver index is less than 30, and metabolic fatty liver disease is expected when it is more than 60. As a result of the research team's analysis of data from about 5.39 million people, 15.5% of them showed moderate (more than 30 to less than 60), and 10% showed high (more than 60).
A follow-up study of the subjects' average 9.4 years of data showed that the group with moderate fatty liver index increased the risk of acute cardiac arrest by 15% compared to the group without, and the risk rose sharply by 55% in the group with high fatty liver index.
Professor Choi Jong-il explained that "1 in 10 young adults in their 20s and 30s had a high fatty liver index, and their risk of acute cardiac arrest was found to be high," and emphasized that "Since young adults are known to have a much lower incidence of acute heart death than the elderly, sudden death related to fatty liver in young adults should be recognized as an important health problem."
In addition, Professor Choi explained that "in addition to the direct increase in the risk of acute cardiac arrest, fatty liver disease could have increased the risk of developing and progressing metabolic syndrome and cardiovascular disease, which are common risk factors for cardiac arrest, leading to an increase in the risk of acute cardiac arrest".
Meanwhile, this study confirmed for the first time that the risk of acute cardiac death increases in young adults according to the MASLD predicted by the fatty liver index, and it is the largest study worldwide. The research paper 'Asociation of Fatty River Index with Sudden Cardiac Arrest in Young Adults' is published in the international journal 'Metabolism - Clinical and Experimental (2023 JCR IF: 10.8)' and is receiving great attention.
Non-alcoholic fatty liver is known to be associated with cardiovascular disease or death as well as liver.
However, there were no established risk factors for acute cardiac arrest in young adults, so research was needed.
In the meantime, Choi Jong-il, a professor of circulatory medicine at Korea University's Anam Hospital (Cho Jong-il, Professor Chung Ju-hee, Professor Lim Sun-young, and Professor Han Kyung-do of the Department of Information Statistics Insurance and Mathematics at Soongsil University), recently conducted a study to confirm that young adults in their 20s and 30s are at increased risk of acute cardiac arrest in the presence of fatty liver.
The research team analyzed data from adults aged 20 to 39 who were screened between 2009 and 2012 through the National Health Insurance Corporation's National Examination Database. The fatty liver index was calculated through BMI, waist circumference, GGT, and triglyceride levels to determine the presence or absence of fatty liver.
Metabolic fatty liver disease is expected to be normal when the fatty liver index is less than 30, and metabolic fatty liver disease is expected when it is more than 60. As a result of the research team's analysis of data from about 5.39 million people, 15.5% of them showed moderate (more than 30 to less than 60), and 10% showed high (more than 60).
A follow-up study of the subjects' average 9.4 years of data showed that the group with moderate fatty liver index increased the risk of acute cardiac arrest by 15% compared to the group without, and the risk rose sharply by 55% in the group with high fatty liver index.
Professor Choi Jong-il explained that "1 in 10 young adults in their 20s and 30s had a high fatty liver index, and their risk of acute cardiac arrest was found to be high," and emphasized that "Since young adults are known to have a much lower incidence of acute heart death than the elderly, sudden death related to fatty liver in young adults should be recognized as an important health problem."
In addition, Professor Choi explained that "in addition to the direct increase in the risk of acute cardiac arrest, fatty liver disease could have increased the risk of developing and progressing metabolic syndrome and cardiovascular disease, which are common risk factors for cardiac arrest, leading to an increase in the risk of acute cardiac arrest".
Meanwhile, this study confirmed for the first time that the risk of acute cardiac death increases in young adults according to the MASLD predicted by the fatty liver index, and it is the largest study worldwide. The research paper 'Asociation of Fatty River Index with Sudden Cardiac Arrest in Young Adults' is published in the international journal 'Metabolism - Clinical and Experimental (2023 JCR IF: 10.8)' and is receiving great attention.
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