Discovered how to lower thrombosis and complications during non-destructive brain aneurysm coil embolization
Oct 03, 2024
When performing coil embolization on non-destructive brain aneurysm patients, domestic researchers have published a study showing that thrombosis and hemorrhagic complications can be reduced by controlling the amount of systemic heparin used according to blood activation coagulation time.
A research team led by Professor Jang Dong-gyu and Professor Cho Byung-rae of Neurosurgery at the Catholic University of Korea's Incheon St. Mary's Hospital recently analyzed data from 288 patients treated for non-destructive brain aneurysms at the Catholic University of Korea's Incheon St. Mary's Hospital.
In the case of non-destructive cerebral aneurysm, intra-cerebrovascular coil embolization treatment has been steadily increasing recently. Coil embolization is a procedure in which the coil is filled so that the swollen brain aneurysm does not grow any larger due to the weakened blood vessels in the brain. At this time, in the case of a complex brain aneurysm, a coil may flow out into the aneurysm inlet. To prevent this, a mesh is inserted, and if platelets stick to it, blood clots can occur well. In the case of mesh-assisted coil embolization performed during the actual treatment of brain aneurysm, embolism was reported up to 49%. If cerebral infarction occurs due to blood clots, aftereffects can occur, so it is most important to perform surgery safely.
In order to reduce these complications, a drug called heparin is used to prevent blood clots, but it is important to use the appropriate amount because high heparin use is likely to cause bleeding.
Professor Jang Dong-gyu's team found through this study that controlling heparin usage based on 250 seconds of activation clotting time helps reduce thrombosis and hemorrhagic complications before and after the procedure. In addition, antiplatelet drugs and systemic heparin are usually used at the same time during mesh-assisted coil embolization, and if the procedure time is prolonged or there is a lot of heparin use, blood clots and bleeding may increase at the same time, suggesting that proper use is required.
Professor Dong-gyu Jang said "Currently, coil embolization is increasing a lot as a treatment method for brain aneurysm, especially under stent-assisted coil embolization, which is known to have a higher incidence of complications."We expect this study to be of great help in getting safer procedures for patients with brain aneurysms in the future."
Meanwhile, Professor Jang Dong-gyu's team's research paper (Feasibility and safety values of activated clotting time-guided systemic heparinization in coil embolization for unrerupted intracranial aneurysms) was published in the European Journal of Neurosurgery 'Acta Neurochirurgica'.
A research team led by Professor Jang Dong-gyu and Professor Cho Byung-rae of Neurosurgery at the Catholic University of Korea's Incheon St. Mary's Hospital recently analyzed data from 288 patients treated for non-destructive brain aneurysms at the Catholic University of Korea's Incheon St. Mary's Hospital.
In the case of non-destructive cerebral aneurysm, intra-cerebrovascular coil embolization treatment has been steadily increasing recently. Coil embolization is a procedure in which the coil is filled so that the swollen brain aneurysm does not grow any larger due to the weakened blood vessels in the brain. At this time, in the case of a complex brain aneurysm, a coil may flow out into the aneurysm inlet. To prevent this, a mesh is inserted, and if platelets stick to it, blood clots can occur well. In the case of mesh-assisted coil embolization performed during the actual treatment of brain aneurysm, embolism was reported up to 49%. If cerebral infarction occurs due to blood clots, aftereffects can occur, so it is most important to perform surgery safely.
In order to reduce these complications, a drug called heparin is used to prevent blood clots, but it is important to use the appropriate amount because high heparin use is likely to cause bleeding.
Professor Jang Dong-gyu's team found through this study that controlling heparin usage based on 250 seconds of activation clotting time helps reduce thrombosis and hemorrhagic complications before and after the procedure. In addition, antiplatelet drugs and systemic heparin are usually used at the same time during mesh-assisted coil embolization, and if the procedure time is prolonged or there is a lot of heparin use, blood clots and bleeding may increase at the same time, suggesting that proper use is required.
Professor Dong-gyu Jang said "Currently, coil embolization is increasing a lot as a treatment method for brain aneurysm, especially under stent-assisted coil embolization, which is known to have a higher incidence of complications."We expect this study to be of great help in getting safer procedures for patients with brain aneurysms in the future."
Meanwhile, Professor Jang Dong-gyu's team's research paper (Feasibility and safety values of activated clotting time-guided systemic heparinization in coil embolization for unrerupted intracranial aneurysms) was published in the European Journal of Neurosurgery 'Acta Neurochirurgica'.
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