"The greater the middle-aged weight variation, the greater the risk of early dementia up to 2.5 times"
Oct 02, 2024
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Professor Ryu Ji-won of Bundang Seoul National University Hospital and Professor Yoon Hyung-jin of Seoul National University Hospital's Medical Engineering Department analyzed data from 3.6 million health examiners aged 40 to 65 in Korea registered in the data of the National Health Insurance Corporation and studied the relationship between the so-called `weight cycle' and the occurrence of early dementia.
Sudden weight changes after middle age can be taken as a health warning. Rapid weight gain or loss is deeply associated with various severe diseases such as cancer, cardiovascular disease, diabetes, decreased immunity, osteoporosis, and cognitive disorders such as dementia, and it is known that the greater the weight change, the higher the mortality rate.
Until now, the relationship between weight changes and physical adverse effects after middle age has been analyzed based on one-way changes that simply rise or fall, but the research team has gained weight It went down or vice versa A study was conducted to analyze the association between the size and cycle of weight cycle and the prevalence of dementia from the perspective of increasing cycles.
The research team analyzed the fluctuations in the weight cycle into four sections: ▶3% or more, ▶5% or more, ▶7% or more, ▶10% or more, using data from 10 years of follow-up of patients who have been examined more than five times every 1-2 years.
As a result, the risk of developing dementia in patients who experienced a weight change cycle of 3% or more increased 1.2 times compared to the normal group of less than 3%, and rose steeply to twice when it was more than 10%. The average age of onset is 58, which is the age group for early dementia.
In addition, the risk of dementia increased by 2.5 times when experiencing two or more weight cycles with fluctuations of 10% or more over the 10-year follow-up period, and the risk of weight fluctuations increased further if the BMI was higher than 25 than those with low BMI.
The findings suggest that the larger and more frequent weight cycles, such as weight loss and weight gain, or weight loss and rapid weight loss, the more adverse brain health and the higher the incidence of early dementia.
Professor Ryu Jie-won said, `The results of a study that evokes awareness of weight management,' `Since excessive changes in weight can adversely affect the human body, such as metabolic stress, it is necessary to focus on stable management so that it does not deviate from the appropriate weight range for middle-aged and older.'
Meanwhile, the results of the study were published in the international academic journal 'Alzheimer's Research & Therapy'.
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