"Periodic diseases such as periodontitis, adverse effects on general health"
Oct 20, 2024
Professor Lee Hyo-jung of dentistry at Seoul National University Bundang Hospital and Professor Kim Hyun-ji and Park Kyung-woon of the Department of Diagnostic Laboratory Medicine said that an unbalanced oral microbial environment worsened by periodontitis can affect the expression of systemic diseases.
Microorganisms, which are known to account for about 2% of our body's weight, form various clusters throughout the human body, such as mouth, intestines, and skin, form a complex and sophisticated ecosystem (microbiome), and affect disease development or prevention by the interaction of beneficial and harmful bacteria.
The representative organ where these microbial communities are located is the oral cavity, and it forms a huge microbial ecosystem, with more than a thousand species of bacteria distributed in the oral cavity and 50 to 1 billion bacteria reported in 1 ml of saliva. It is also well known that the deterioration of the oral microbial environment is closely related to the increased incidence of systemic diseases such as diabetes, cardiovascular disease, cancer, and dementia.
However, the method and path of how the microbial community in the oral cavity affects the microbiome and even systemic diseases across the human body have not yet been fully identified. The research team wanted to find a clue through a metagenomic study comparing and analyzing genomic DNA data extracted from patients with periodontitis and healthy patients stored at Seoul National University Bundang Hospital.
The research team conducted dielectric sequencing based on ▶ saliva (spine) ▶ oral wall ▶ oral plaque ▶ stool ▶ blood data of periodontitis patients, and found that the composition and ratio of periodontitis-related microorganisms observed in saliva and dental plaque of periodontitis patients were identified in the blood. This suggests that blood can play a role as a marker to identify the mechanism by which periodontal diseases such as periodontitis affect systemic diseases.
This study is an important study that can investigate the relationship between oral health and various systemic diseases such as diabetes, arteriosclerosis, and cancer, and is meaningful in that it has provided clues to reveal the mechanism by which oral health affects the whole body by confirming the existence of an oral-blood microbial axis that forms a habitat in the blood.
Professor Lee Hyo-jung said, "We need to pay more attention to oral health care, recognizing that periodontal inflammation that worsens the microbial environment in the oral cavity can adversely affect the whole body." he said.
Meanwhile, the results of this study can be found in the international journal 『Journal of Oral Microbiology』.
Microorganisms, which are known to account for about 2% of our body's weight, form various clusters throughout the human body, such as mouth, intestines, and skin, form a complex and sophisticated ecosystem (microbiome), and affect disease development or prevention by the interaction of beneficial and harmful bacteria.
The representative organ where these microbial communities are located is the oral cavity, and it forms a huge microbial ecosystem, with more than a thousand species of bacteria distributed in the oral cavity and 50 to 1 billion bacteria reported in 1 ml of saliva. It is also well known that the deterioration of the oral microbial environment is closely related to the increased incidence of systemic diseases such as diabetes, cardiovascular disease, cancer, and dementia.
However, the method and path of how the microbial community in the oral cavity affects the microbiome and even systemic diseases across the human body have not yet been fully identified. The research team wanted to find a clue through a metagenomic study comparing and analyzing genomic DNA data extracted from patients with periodontitis and healthy patients stored at Seoul National University Bundang Hospital.
The research team conducted dielectric sequencing based on ▶ saliva (spine) ▶ oral wall ▶ oral plaque ▶ stool ▶ blood data of periodontitis patients, and found that the composition and ratio of periodontitis-related microorganisms observed in saliva and dental plaque of periodontitis patients were identified in the blood. This suggests that blood can play a role as a marker to identify the mechanism by which periodontal diseases such as periodontitis affect systemic diseases.
This study is an important study that can investigate the relationship between oral health and various systemic diseases such as diabetes, arteriosclerosis, and cancer, and is meaningful in that it has provided clues to reveal the mechanism by which oral health affects the whole body by confirming the existence of an oral-blood microbial axis that forms a habitat in the blood.
Professor Lee Hyo-jung said, "We need to pay more attention to oral health care, recognizing that periodontal inflammation that worsens the microbial environment in the oral cavity can adversely affect the whole body." he said.
Meanwhile, the results of this study can be found in the international journal 『Journal of Oral Microbiology』.
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