Professor Kang Hee-jung and Noh Joo-hye of Hallym University Sacred Heart Hospital, Outstanding Performance in the International Academic Conference of the Korean Society of Diagnostic Test and Medicine
Oct 29, 2024
Professor Kang Hee-jung and Noh Joo-hye of the Department of Diagnostic Laboratory Medicine at Hallym University Sacred Heart Hospital (Hospital Director Kim Hyung-soo) won the Excellence Award at the '2024 International Conference on Diagnostic Laboratory Medicine (LMCE 2024 & KSLM 65th Annual Meeting)' held at the COEX Convention Center from September 25 to 27.
Professor Kang Hee-jung and Professor Noh Joo-hye analyzed the effectiveness and safety of primate transfusions in wild-type and triple-gene knockout pig RBC transmissions in nonhuman primates for the first time in the world.
The research team paid attention to genetically modified pigs. Pigs have similar anatomical and physiological characteristics to humans, such as organ size and red blood cell function. As research is already actively underway to replace genetically modified pig organs with human organs, the possibility has been explored in pig blood.
The study was conducted by transfusing and observing red blood cells from triple-gene removal (TKO) pigs and general experimental sterile (WT) pigs, which improved their suitability with human blood through genetic modification, to primates similar to humans. The results showed that the hematologic indicators improved effectively by 24 hours after transfusion and that TKO porcine erythrocytes had less systemic side effects than WT porcine erythrocytes. However, after 24 h, transfused porcine erythrocytes were rapidly removed from the circulatory system due to antibody responses, and the benefits and limitations of heterologous transfusions were simultaneously observed.
The presentation drew a lot of attention from participants in international academic conferences as it was the first analysis to be attempted as a cross-species blood transfusion study. It was also highly praised for laying the groundwork for the development of new blood alternatives.
Professor Kang Hee-jung, the head of the research, said, "(Based on the basic data obtained through this study, we will continue our research to ensure that pig red blood cells can replace human red blood cells,' adding, "(We will work hard to develop additional pig genetic modifications, immunosuppression studies, and effective heterologous blood transfusion protocols.'
This study is being carried out as a joint technology development project of the Civil Military Cooperation Promotion Agency of the National Defense Research Institute, jointly invested by the Ministry of Trade, Industry and Energy and the Defense Acquisition Program Administration.
Professor Kang Hee-jung and Professor Noh Joo-hye analyzed the effectiveness and safety of primate transfusions in wild-type and triple-gene knockout pig RBC transmissions in nonhuman primates for the first time in the world.
The research team paid attention to genetically modified pigs. Pigs have similar anatomical and physiological characteristics to humans, such as organ size and red blood cell function. As research is already actively underway to replace genetically modified pig organs with human organs, the possibility has been explored in pig blood.
The study was conducted by transfusing and observing red blood cells from triple-gene removal (TKO) pigs and general experimental sterile (WT) pigs, which improved their suitability with human blood through genetic modification, to primates similar to humans. The results showed that the hematologic indicators improved effectively by 24 hours after transfusion and that TKO porcine erythrocytes had less systemic side effects than WT porcine erythrocytes. However, after 24 h, transfused porcine erythrocytes were rapidly removed from the circulatory system due to antibody responses, and the benefits and limitations of heterologous transfusions were simultaneously observed.
The presentation drew a lot of attention from participants in international academic conferences as it was the first analysis to be attempted as a cross-species blood transfusion study. It was also highly praised for laying the groundwork for the development of new blood alternatives.
Professor Kang Hee-jung, the head of the research, said, "(Based on the basic data obtained through this study, we will continue our research to ensure that pig red blood cells can replace human red blood cells,' adding, "(We will work hard to develop additional pig genetic modifications, immunosuppression studies, and effective heterologous blood transfusion protocols.'
This study is being carried out as a joint technology development project of the Civil Military Cooperation Promotion Agency of the National Defense Research Institute, jointly invested by the Ministry of Trade, Industry and Energy and the Defense Acquisition Program Administration.
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