"Coffee, independent of liver disease-related mortality, helps overall survival rates"
Nov 26, 2024
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A team of professors of gastroenterology at Soonchunhyang University Seoul Hospital (Jang Jae-young, Jeong Seung-won, Jang Young, and Yang Kyung-mo, clinical instructor of gastroenterology at Seoul St. Mary's Hospital) used UK Biobank data to evaluate the effect of coffee consumption on Metabolic Dysfunctionalio-associated live disease (MASLD) and Metalcoholic intake (MetALD).
Existing studies have shown that coffee can suppress the progression of liver disease, but in this study, inverse probability treatment weighting (IPTW) was applied to more accurately analyze the effect of coffee consumption on liver disease-related survival rates to correct other confusion variables.
A total of 455,870 people were divided into a group without fatty liver, a group with metabolic abnormal fatty liver disease, and a group with metabolic alcoholic fatty liver disease, and large-scale cohort analysis was conducted by dividing them into 0 cups of coffee, 1 to 2 cups, and 3 cups or more per day.
As a result of the analysis, it was found that one to two cups of coffee per day increased liver disease-related survival rates in both the group without fatty liver, the group with metabolic abnormal fatty liver disease, and the group with metabolic alcoholic fatty liver disease before applying the inverse probability weight.
However, after applying the inverse probability weight, coffee consumption was found to have no effect on liver disease-related mortality in both metabolic and alcoholic fatty liver patients.
Professor Liu Dam "It was confirmed that coffee consumption had a positive effect on overall survival, but not significantly on liver disease-related mortality."In previous studies, additional tools called confusion variable correction were used, and more accurate analysis of variables was performed."
The paper was published in the journal Nutrients under the title Reassessing the Impact of Coffee Consumption on Liver Diseases: Insights from a Large-Scale Cohort Study with IPTW Adjustment.
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