Gangdong Kyunghee University Hospital succeeded in surgery for other living liver transplants of blood types 'high difficulty'
Nov 27, 2024
Gangdong Kyunghee University Hospital (Director Lee Woo-in) Organ Transplant Center (Professor Seon-hyeong and Professor Lee Seung-hwan) succeeded in blood type mismatch living liver transplantation.
Blood type mismatched living body liver transplantation is also known as the most difficult surgery in the transplantation field. If the blood type is different, there is a high risk of complications due to antibody rejection. Depending on the patient, severe cases can lead to death. Professor Joo Sun-hyung and Professor Lee Seung-hwan's team, along with professional medical staff at the organ transplant center, were able to reduce antibody rejection with appropriate procedures and medications before and after surgery, and successfully transplant blood type mismatch by performing high-level surgery based on abundant experience.
A 58-year-old man was a terminal cirrhosis patient, and despite various treatments, he decided to transplant because he could no longer recover his liver function. Although it was decided as a living liver transplant between family members, blood type mismatch living liver transplantation was performed due to different blood types between the patient and the donor. The operation was carried out on October 25, and it was successfully completed within nine hours. The patient recovered smoothly and was discharged in good health on November 21 before less than a month after surgery.
Living liver transplantation is a surgery in which a healthy person's left lobe or part of the left lobe or right lobe is removed and transplanted to patients with end-stage liver disease. The liver has unique characteristics that allow it to maintain its function even with only a small portion, so if the size of the liver that remains in the donor and the segmental liver that is donated to the recipient is more than a certain level, both the donor and the recipient can maintain sufficient function.
In Korea, the supply of organs for brain-dead people is insufficient, and about 70% of all liver transplants are performed by living liver transplants. In the case of brain-dead liver transplantation, transplantation is performed in a critical condition where the liver function is very low and the patient can die soon, whereas living liver transplantation is known to have a higher success rate and survival rate because transplantation is performed while the liver function is preserved to some extent and the patient's condition is maintained.
Blood type mismatched living body liver transplantation is a high-level surgery that is possible only after years of liver transplantation experience.
This is because antigen-antibody rejection due to other blood types can cause complications that can lead to death. Technically perfect transplantation is required, and it is also very important to control rejection before and after surgery.
Prior to surgery, treatment is preceded by inhibiting the activity of B lymphocytes, a key cell in the immune response, and reducing the titer of serum agglutinin to reduce rejection in the recipient. Plasma exchange is performed according to the results of serum coagulant titer, and the titer is adjusted to a state where transplantation is possible. Continuous immunosuppressive quality control and infection control following the use of immunosuppressants are essential even after surgery, and it is important to identify the signs of rejection or infection very early and start rapid treatment.
In the end, it is important to select a medical institution with a systematic multidisciplinary transplant system as well as a competent surgeon who is excellent for transplantation.
The organ transplant center at Gangdong Kyunghee University Hospital is equipped with both systematic medical services and excellent medical staff necessary for organ transplantation. In 2008, it was the first successful living part liver transplantation in Korea for patients with 'urometabolic dysplasia', and it has been continuously undergoing living part liver transplantation. With the success of this blood type mismatch living body liver transplantation, the competitiveness of organ transplantation has been raised to the next level.
Blood type mismatched living body liver transplantation is also known as the most difficult surgery in the transplantation field. If the blood type is different, there is a high risk of complications due to antibody rejection. Depending on the patient, severe cases can lead to death. Professor Joo Sun-hyung and Professor Lee Seung-hwan's team, along with professional medical staff at the organ transplant center, were able to reduce antibody rejection with appropriate procedures and medications before and after surgery, and successfully transplant blood type mismatch by performing high-level surgery based on abundant experience.
A 58-year-old man was a terminal cirrhosis patient, and despite various treatments, he decided to transplant because he could no longer recover his liver function. Although it was decided as a living liver transplant between family members, blood type mismatch living liver transplantation was performed due to different blood types between the patient and the donor. The operation was carried out on October 25, and it was successfully completed within nine hours. The patient recovered smoothly and was discharged in good health on November 21 before less than a month after surgery.
Living liver transplantation is a surgery in which a healthy person's left lobe or part of the left lobe or right lobe is removed and transplanted to patients with end-stage liver disease. The liver has unique characteristics that allow it to maintain its function even with only a small portion, so if the size of the liver that remains in the donor and the segmental liver that is donated to the recipient is more than a certain level, both the donor and the recipient can maintain sufficient function.
In Korea, the supply of organs for brain-dead people is insufficient, and about 70% of all liver transplants are performed by living liver transplants. In the case of brain-dead liver transplantation, transplantation is performed in a critical condition where the liver function is very low and the patient can die soon, whereas living liver transplantation is known to have a higher success rate and survival rate because transplantation is performed while the liver function is preserved to some extent and the patient's condition is maintained.
Blood type mismatched living body liver transplantation is a high-level surgery that is possible only after years of liver transplantation experience.
This is because antigen-antibody rejection due to other blood types can cause complications that can lead to death. Technically perfect transplantation is required, and it is also very important to control rejection before and after surgery.
Prior to surgery, treatment is preceded by inhibiting the activity of B lymphocytes, a key cell in the immune response, and reducing the titer of serum agglutinin to reduce rejection in the recipient. Plasma exchange is performed according to the results of serum coagulant titer, and the titer is adjusted to a state where transplantation is possible. Continuous immunosuppressive quality control and infection control following the use of immunosuppressants are essential even after surgery, and it is important to identify the signs of rejection or infection very early and start rapid treatment.
In the end, it is important to select a medical institution with a systematic multidisciplinary transplant system as well as a competent surgeon who is excellent for transplantation.
The organ transplant center at Gangdong Kyunghee University Hospital is equipped with both systematic medical services and excellent medical staff necessary for organ transplantation. In 2008, it was the first successful living part liver transplantation in Korea for patients with 'urometabolic dysplasia', and it has been continuously undergoing living part liver transplantation. With the success of this blood type mismatch living body liver transplantation, the competitiveness of organ transplantation has been raised to the next level.
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