Identify the risk and predictive factors of deterioration of the opposite brain after surgery on one side of the brain of Moya moya disease
Nov 26, 2024
A research team led by Professor Lee Si-woon of Bundang Seoul National University Hospital has published the results of a study that revealed the risk and predictors of deterioration of moeyamoya disease in the opposite brain after only one of the patients with moeyamoya disease underwent cerebrovascular surgery.
Moyamoya disease is a disease in which the main blood vessels that supply blood to the brain gradually narrow and block, and if the brain does not supply enough blood, it can cause serious brain damage such as stroke and cerebral hemorrhage, so active treatment and management are important.
Most of the moyamoya disease occurs in both brains, and for treatment, cerebrovascular anastomosis surgery is performed to increase cerebral blood flow by connecting blood vessels outside the brain and blood vessels inside the brain. In general, the side of the brain with severe symptoms is operated first, and the other side of the brain is often treated additionally if necessary. However, after performing surgery on one brain, research on the criteria for predicting how the disease in the other brain will progress was still insufficient.
Accordingly, the research team conducted a study to analyze the possibility of the disease progressing to the other brain after surgery only one of the patients with moya moya disease on both sides and the risk factors, and followed 174 patients who underwent cerebrovascular anastomosis in one brain for an average of 45 months from 2003 to 2022 at Seoul National University Bundang Hospital.
Results showed that 57 out of 174 patients (approximately 32.8%) underwent additional cerebrovascular anastomosis due to deterioration of moyamoya disease in the opposite brain that had not undergone surgery during the observation period. The annual progression rate to the opposite brain is 7.7%, which means that lesions in the opposite brain may worsen in an additional 7 to 8 out of 100 patients each year.
In particular, patients with a BMI of 25 or higher deteriorated 12.1% per year, about three times higher than the annual progression rate of 4.0% in patients with a BMI of less than 25. Based on these findings, the research team suggested that weight management is an important factor in suppressing the progression of moyamoya disease, and that careful observation and management are needed through long-term monitoring even after surgery.
Professor Bang Jae-seung said, "This is the first study to suggest factors that can predict disease progression in the other brain after treatment of one brain in patients with bilateral moyamoya disease. This will enable more customized management and preventive approaches for high-risk patients."
Professor Lee Si-woon said, "It is meaningful in that it has laid the foundation for scientifically predicting the possibility of deterioration of Moyamoya disease by identifying objective indicators for predicting the progression of the disease."
Meanwhile, the results of this study were published in the SCIE-level international journal 『Journal of Neurosurgery』, which is considered a credible journal in the field of neurosurgery.
Moyamoya disease is a disease in which the main blood vessels that supply blood to the brain gradually narrow and block, and if the brain does not supply enough blood, it can cause serious brain damage such as stroke and cerebral hemorrhage, so active treatment and management are important.
Most of the moyamoya disease occurs in both brains, and for treatment, cerebrovascular anastomosis surgery is performed to increase cerebral blood flow by connecting blood vessels outside the brain and blood vessels inside the brain. In general, the side of the brain with severe symptoms is operated first, and the other side of the brain is often treated additionally if necessary. However, after performing surgery on one brain, research on the criteria for predicting how the disease in the other brain will progress was still insufficient.
Accordingly, the research team conducted a study to analyze the possibility of the disease progressing to the other brain after surgery only one of the patients with moya moya disease on both sides and the risk factors, and followed 174 patients who underwent cerebrovascular anastomosis in one brain for an average of 45 months from 2003 to 2022 at Seoul National University Bundang Hospital.
Results showed that 57 out of 174 patients (approximately 32.8%) underwent additional cerebrovascular anastomosis due to deterioration of moyamoya disease in the opposite brain that had not undergone surgery during the observation period. The annual progression rate to the opposite brain is 7.7%, which means that lesions in the opposite brain may worsen in an additional 7 to 8 out of 100 patients each year.
In particular, patients with a BMI of 25 or higher deteriorated 12.1% per year, about three times higher than the annual progression rate of 4.0% in patients with a BMI of less than 25. Based on these findings, the research team suggested that weight management is an important factor in suppressing the progression of moyamoya disease, and that careful observation and management are needed through long-term monitoring even after surgery.
Professor Bang Jae-seung said, "This is the first study to suggest factors that can predict disease progression in the other brain after treatment of one brain in patients with bilateral moyamoya disease. This will enable more customized management and preventive approaches for high-risk patients."
Professor Lee Si-woon said, "It is meaningful in that it has laid the foundation for scientifically predicting the possibility of deterioration of Moyamoya disease by identifying objective indicators for predicting the progression of the disease."
Meanwhile, the results of this study were published in the SCIE-level international journal 『Journal of Neurosurgery』, which is considered a credible journal in the field of neurosurgery.
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