If you have depression, you're more likely to have a stroke after coronary intervention
Nov 07, 2024
Cardiovascular disease is the leading cause of death worldwide and ranks second in Korea as the leading cause of death.
Major cardiovascular diseases include angina or myocardial infarction in which the coronary arteries are blocked or narrowed, and relatively safe and non-invasive percutaneous coronary intervention is widely performed for treatment. However, studies have shown that patients with cardiovascular disease with depression have an increased risk of stroke and early death when they undergo percutaneous coronary intervention.
Professor Lee Min-woo of the Department of Neurology at Hallim University Sacred Heart Hospital (co-corresponding author), Professor Chun Dae-young of the Department of Circulatory Mechanics at Hallim University Dongtan Sacred Heart Hospital (1 author), and Professor Han Kyung-do of the Department of Information Statistics Insurance Mathematics at Soongsil University (co-corresponding author) have confirmed the above information in the Depression and Risk of Stroke and Mortality After Percutaneous Coronary Intervention: A Nationwide Population Study).
The research team analyzed 164,198 people who underwent percutaneous coronary intervention from January 2010 to December 2017 using medical data from the National Health Insurance Service. Among them, 28,560 patients (17.4%) were previously diagnosed with depression. The research team compared acute stroke occurrence, early mortality risk, coronary artery reopening or coronary artery bypass after cardiovascular disease treatment in the group diagnosed with depression and the group that did not.
As a result, out of 28,560 people in the group with depression, 1468 (5.7%) suffered acute strokes after percutaneous coronary intervention, but 4,748 (3.5%) out of 135,638 people in the group without depression suffered acute strokes. Adjusting the variables showed that the group with depression had a 27% higher risk of acute stroke than the group without depression.
In addition, the risk of early death was 25% higher in the depression group than in the depression-free group. The depression group also had an 8% higher risk of re-opening or coronary artery bypass because cardiovascular vessels were blocked again. If the period of depression was more than 5 years, the risk of early death was 7% higher than that of less than 5 years.
In particular, age-specific analysis showed a 48% increase in the risk of stroke associated with depression in the group under 65 years of age. This is 2.5 times higher than the 19% increase in the risk of depression-related stroke in the 65-year-old group. In addition, the group under 65 years of age had more than twice the risk of early death than the group over 65 years of age.
Meanwhile, patients diagnosed with depression were more likely to be older and female or to have diseases such as diabetes, hypertension, dyslipidemia, atrial fibrillation, and chronic kidney disease.
Professor Minwoo Lee "This study confirmed a new association between depression and increased risk of stroke after percutaneous coronary intervention."In patients with cardiovascular disease with depression, the prognosis and quality of life of patients can be improved through mental health assessment and depression management before and after the procedure."
Professor Lee also said "In particular, while the prevalence of cardiovascular disease and depression has been increasing recently among those under the age of 65, side effects from depression are greater among those under the age of 65, confirming the importance of mental health checkups and active intervention in the treatment of young cardiovascular disease patients."
The paper was published in the October issue of the SCIE-level international journal 'Journal of Internal Medicine, Index of Papers (IF: 9.0)'.
Major cardiovascular diseases include angina or myocardial infarction in which the coronary arteries are blocked or narrowed, and relatively safe and non-invasive percutaneous coronary intervention is widely performed for treatment. However, studies have shown that patients with cardiovascular disease with depression have an increased risk of stroke and early death when they undergo percutaneous coronary intervention.
Professor Lee Min-woo of the Department of Neurology at Hallim University Sacred Heart Hospital (co-corresponding author), Professor Chun Dae-young of the Department of Circulatory Mechanics at Hallim University Dongtan Sacred Heart Hospital (1 author), and Professor Han Kyung-do of the Department of Information Statistics Insurance Mathematics at Soongsil University (co-corresponding author) have confirmed the above information in the Depression and Risk of Stroke and Mortality After Percutaneous Coronary Intervention: A Nationwide Population Study).
The research team analyzed 164,198 people who underwent percutaneous coronary intervention from January 2010 to December 2017 using medical data from the National Health Insurance Service. Among them, 28,560 patients (17.4%) were previously diagnosed with depression. The research team compared acute stroke occurrence, early mortality risk, coronary artery reopening or coronary artery bypass after cardiovascular disease treatment in the group diagnosed with depression and the group that did not.
As a result, out of 28,560 people in the group with depression, 1468 (5.7%) suffered acute strokes after percutaneous coronary intervention, but 4,748 (3.5%) out of 135,638 people in the group without depression suffered acute strokes. Adjusting the variables showed that the group with depression had a 27% higher risk of acute stroke than the group without depression.
In addition, the risk of early death was 25% higher in the depression group than in the depression-free group. The depression group also had an 8% higher risk of re-opening or coronary artery bypass because cardiovascular vessels were blocked again. If the period of depression was more than 5 years, the risk of early death was 7% higher than that of less than 5 years.
In particular, age-specific analysis showed a 48% increase in the risk of stroke associated with depression in the group under 65 years of age. This is 2.5 times higher than the 19% increase in the risk of depression-related stroke in the 65-year-old group. In addition, the group under 65 years of age had more than twice the risk of early death than the group over 65 years of age.
Meanwhile, patients diagnosed with depression were more likely to be older and female or to have diseases such as diabetes, hypertension, dyslipidemia, atrial fibrillation, and chronic kidney disease.
Professor Minwoo Lee "This study confirmed a new association between depression and increased risk of stroke after percutaneous coronary intervention."In patients with cardiovascular disease with depression, the prognosis and quality of life of patients can be improved through mental health assessment and depression management before and after the procedure."
Professor Lee also said "In particular, while the prevalence of cardiovascular disease and depression has been increasing recently among those under the age of 65, side effects from depression are greater among those under the age of 65, confirming the importance of mental health checkups and active intervention in the treatment of young cardiovascular disease patients."
The paper was published in the October issue of the SCIE-level international journal 'Journal of Internal Medicine, Index of Papers (IF: 9.0)'.
|
bellho@sportschosun.com
