"Intermittent fasting, metabolic abnormalities reducing fatty liver effects"
Nov 19, 2024
'metabolic fatty liver disease', which has a high prevalence of about 30% in domestic adults, is a disease in which fat is deposited in the liver and is closely related to metabolic diseases such as obesity, hyperlipidemia, and diabetes. If fatty liver disease progresses, liver-related complications such as hepatitis, cirrhosis, and liver cancer can occur, and active treatment is required due to the high risk of cardiovascular disease and resulting mortality.
However, since effective fatty liver treatments have not been introduced in Korea, weight loss through diet and exercise therapy is the most important treatment method. Until now, effective diets for treating metabolic abnormal fatty liver disease have not been well known, but research results showing that 'intermittent fasting' is effective for treating fatty liver have recently been published, drawing attention.
A research team led by Professor Lee Han-ah of the Department of Gastroenterology at Chung-Ang University Hospital recently published a research paper on the effect of intermittent calorie restriction in non-diabetic patients with metabolic abnormal fatty liver disease.
Professor Lee Han-ah's research team divided non-diabetic patients with metabolic abnormal fatty liver disease into two groups and compared and analyzed the effects of intermittent calorie restriction (ICR) and standard of care (SOC) for 12 weeks.
As a result, patients with a greater percentage of fat reduction in their liver by 30% or more compared to one group with a 5:2 intermittent calorie restriction (ICR, 5 days of the week consumed less than 2,000 to 2500 kcal in three meals and 500 to 600 kcal in two days) compared to one group with a standard diet (SOC; 80% of the recommended calorie intake per three meals per week, 1200 to 1800 kcal intake) (72.2% vs. 44.4%).
In particular, obese people had a greater effect on reducing fatty liver through intermittent calorie-restricted diets than those who were not obese, and were also found to be effective in weight loss (relative weight loss ratio 5.5% vs. 2.9%).
As a result, the research team confirmed that the intermittent calorie restriction (5:2 diet) diet can be an effective treatment for obese fatty liver patients.
Professor Lee Han-ah recommends that obese people actively practice non-pharmaceutical treatments because intermittent calorie restriction twice a week is effective in fatty liver and weight lossHe stressed that early prevention through active diet management is necessary because it can lead to hepatitis, cirrhosis, and liver cancer if left unattended without considering that fatty liver is common.
This research paper was published in the latest issue of the SCIE-level international journal 'Clinical Gastroenterology & Heptology'.
However, since effective fatty liver treatments have not been introduced in Korea, weight loss through diet and exercise therapy is the most important treatment method. Until now, effective diets for treating metabolic abnormal fatty liver disease have not been well known, but research results showing that 'intermittent fasting' is effective for treating fatty liver have recently been published, drawing attention.
A research team led by Professor Lee Han-ah of the Department of Gastroenterology at Chung-Ang University Hospital recently published a research paper on the effect of intermittent calorie restriction in non-diabetic patients with metabolic abnormal fatty liver disease.
Professor Lee Han-ah's research team divided non-diabetic patients with metabolic abnormal fatty liver disease into two groups and compared and analyzed the effects of intermittent calorie restriction (ICR) and standard of care (SOC) for 12 weeks.
As a result, patients with a greater percentage of fat reduction in their liver by 30% or more compared to one group with a 5:2 intermittent calorie restriction (ICR, 5 days of the week consumed less than 2,000 to 2500 kcal in three meals and 500 to 600 kcal in two days) compared to one group with a standard diet (SOC; 80% of the recommended calorie intake per three meals per week, 1200 to 1800 kcal intake) (72.2% vs. 44.4%).
In particular, obese people had a greater effect on reducing fatty liver through intermittent calorie-restricted diets than those who were not obese, and were also found to be effective in weight loss (relative weight loss ratio 5.5% vs. 2.9%).
As a result, the research team confirmed that the intermittent calorie restriction (5:2 diet) diet can be an effective treatment for obese fatty liver patients.
Professor Lee Han-ah recommends that obese people actively practice non-pharmaceutical treatments because intermittent calorie restriction twice a week is effective in fatty liver and weight lossHe stressed that early prevention through active diet management is necessary because it can lead to hepatitis, cirrhosis, and liver cancer if left unattended without considering that fatty liver is common.
This research paper was published in the latest issue of the SCIE-level international journal 'Clinical Gastroenterology & Heptology'.
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