"Placenta injection is effective in treating atopic dermatitis"
Nov 26, 2024
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Meanwhile, a recent domestic study has shown that human placental extract (HPH; Human Placenta Hydrolysate) can be effective in treating 'atopic dermatitis', drawing attention.
Professor Kim Bum-joon of the Department of Dermatology at Chung-Ang University Hospital (Dr. Lee Jung-ok of the Department of Dermatology at Chung-Ang University) recently published a research paper (Human Placenta Extract (HPH) Suppress Inflammatory Responses in TNF-α/IFN-γ-Stimulated HaCaT Cells and a DNCB Atopic Dermatitis (AD)-Like Mouse Model) on the treatment of atopic dermatitis in human keratinocytes and atopic dermatitis mouse models.
The 'human placenta extract (HPH)' is called the placenta injection, which separates and removes blood and hormones from the human placenta, breaks down the remaining protein into amino acids, and uses them as injection components. It contains various physiologically active substances to reduce inflammation, improve fatigue, and help heal wounds, but so far, the effect has not been confirmed in treating atopic dermatitis.
Professor Kim Bum-joon's research team applied a mixture of DNCD (2,4-dinitrochlorobenzene), a substance that causes atopic dermatitis, to the back of mice in human keratinocytes (HaCaT) and atopic dermatitis to induce atopic dermatitis, while at the same time injecting 'human placenta extract (HPH)' and 'Dexamethasone (DEX)', which were used as existing skin inflammation treatments, into subcutaneous and abdominal injections, respectively, to evaluate the effectiveness of atopic dermatitis treatment.
As a result, it was confirmed that the injection of 'human placenta extract (HPH) significantly reduced the production of reactive oxygen (ROS) in human keratinocytes (HaCaT), thereby inhibiting oxidative stress.
In addition, in the atopic dermatitis mouse model injected with 'Human Placenta Extract (HPH)', the concentration of IL-4 and IgE, the main cytokines of atopic skin inflammation, decreased by 60% and 27%, respectively, and macrophage infiltration and epidermal thickness were reduced to improve atopic skin lesions.
As a result, the research team confirmed through this study that the injection of 'Human Placenta Extract (HPH)' effectively suppresses the progression of atopic dermatitis and can be used as a useful treatment for atopic dermatitis-like skin diseases.
Professor Kim Bum-joon "We hope that future research will continue to see if it can be applied to atopic dermatitis patients through full-scale clinical research after laboratory research and animal testing."If expensive biological agents are difficult to use or are not eligible for treatment, we believe HPH injections can also be used as an option for atopic dermatitis treatments" he said.
Meanwhile, this research paper was published in the latest issue of the SCIE-level international journal Journal of Microbiology and Biotechnology, and was selected as an excellent paper by the Korean Society of Microbiology and Biotechnology (KMB).
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