Proving the stability and effectiveness of high-intensity ultrasound brain surgery for the world's first obsessive-compulsive disorder patient
Nov 07, 2024
Professor Jang Jin-woo of neurosurgery at Korea University Anam Hospital proved the stability and long-term effectiveness of high-intensity ultrasound brain surgery in obsessive compulsive disorder.
Obsessive compulsive disorder is a common mental disorder characterized by compulsive thinking and behavior. Drug therapy and cognitive behavioral therapy are combined, but most of them occur at a young age, so the treatment effect is insufficient and recurrence is frequent.
High-frequency thermal coagulation and deep brain stimulation are used as surgical treatments, but there is a risk of infection and bleeding because craniotomy is required. In the case of gamma knife surgery, swelling and delayed cysts may occur as a side effect of high-dose radiation administration.
A research team led by Professor Jang Jin-woo of Neurosurgery at Korea University Anam Hospital (Professor Jang Kyung-won of Neurosurgery at Sungkyunkwan University) and Professor Kim Se-joo of the Department of Mental Health Medicine at Yonsei University School of Medicine (Professor Jang Jin-koo of Hanyang University) performed bilateral brain pre-epithelial resection using high-intensity ultrasound brain surgery techniques on 11 patients diagnosed with obsessive compulsive disorder from 2013 to 2014, and 10 of them were followed up for more than 10 years.
As a result of the study, 7 out of 10 patients who were able to follow up for more than 10 years showed a complete response (reduced YBOCS (stiffness scale test) score of more than 35% after treatment), and 2 of them were completely remembered. The average YBOCS score of 10 patients also improved by 52.3%, improving their quality of life, and all 11 patients did not develop any serious side effects after ultrasound surgery.
Professor Jang Jin-woo said "Confident ultrasound brain surgery is less psychological burden on patients because it is non-invasive than craniotomy. There is no risk of infection or bleeding, and the precision of surgery is high, so unnecessary brain damage around the treatment site can be avoided, so it is currently the safest surgical method."
Since Professor Jang Jin-woo's world's first ultrasound surgery on obsessive-compulsive disorder patients, other countries such as Canada have recently performed high-intensity ultrasound brain surgery on obsessive-compulsive disorder patients to confirm similar surgical effects.
Professor Jang Jin-woo's thesis is significant in that it contains 10 years of follow-up clinical data, the longest period after OCD surgery. This confirms that ultrasound brain surgery can play an important role in the treatment of patients with obsessive-compulsive disorder, and at the same time is expected to bring about a paradigm shift with new treatments.
Professor Jang Jin-woo said, `I hope this study will serve as a cornerstone for the application of high-intensity ultrasound brain surgery to various mental diseases in the future.' `I also hope that this surgery will contribute to the return of many patients with obsessive compulsive disorder or depression to a healthy daily life.'
Professor Jang Jin-woo's paper 'Long-term clinical come of a novel bileral capsulotomy with focused ultrasound in refactory obsessive-compulsive disorder treatment' was published in the October issue of Molecular Psychiatry (IF 9.6), the top academic journal in the field of psychiatry.
Obsessive compulsive disorder is a common mental disorder characterized by compulsive thinking and behavior. Drug therapy and cognitive behavioral therapy are combined, but most of them occur at a young age, so the treatment effect is insufficient and recurrence is frequent.
High-frequency thermal coagulation and deep brain stimulation are used as surgical treatments, but there is a risk of infection and bleeding because craniotomy is required. In the case of gamma knife surgery, swelling and delayed cysts may occur as a side effect of high-dose radiation administration.
A research team led by Professor Jang Jin-woo of Neurosurgery at Korea University Anam Hospital (Professor Jang Kyung-won of Neurosurgery at Sungkyunkwan University) and Professor Kim Se-joo of the Department of Mental Health Medicine at Yonsei University School of Medicine (Professor Jang Jin-koo of Hanyang University) performed bilateral brain pre-epithelial resection using high-intensity ultrasound brain surgery techniques on 11 patients diagnosed with obsessive compulsive disorder from 2013 to 2014, and 10 of them were followed up for more than 10 years.
As a result of the study, 7 out of 10 patients who were able to follow up for more than 10 years showed a complete response (reduced YBOCS (stiffness scale test) score of more than 35% after treatment), and 2 of them were completely remembered. The average YBOCS score of 10 patients also improved by 52.3%, improving their quality of life, and all 11 patients did not develop any serious side effects after ultrasound surgery.
Professor Jang Jin-woo said "Confident ultrasound brain surgery is less psychological burden on patients because it is non-invasive than craniotomy. There is no risk of infection or bleeding, and the precision of surgery is high, so unnecessary brain damage around the treatment site can be avoided, so it is currently the safest surgical method."
Since Professor Jang Jin-woo's world's first ultrasound surgery on obsessive-compulsive disorder patients, other countries such as Canada have recently performed high-intensity ultrasound brain surgery on obsessive-compulsive disorder patients to confirm similar surgical effects.
Professor Jang Jin-woo's thesis is significant in that it contains 10 years of follow-up clinical data, the longest period after OCD surgery. This confirms that ultrasound brain surgery can play an important role in the treatment of patients with obsessive-compulsive disorder, and at the same time is expected to bring about a paradigm shift with new treatments.
Professor Jang Jin-woo said, `I hope this study will serve as a cornerstone for the application of high-intensity ultrasound brain surgery to various mental diseases in the future.' `I also hope that this surgery will contribute to the return of many patients with obsessive compulsive disorder or depression to a healthy daily life.'
Professor Jang Jin-woo's paper 'Long-term clinical come of a novel bileral capsulotomy with focused ultrasound in refactory obsessive-compulsive disorder treatment' was published in the October issue of Molecular Psychiatry (IF 9.6), the top academic journal in the field of psychiatry.
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