"Viomarker identification of severe knee arthritis requiring artificial joint replacement"
Nov 11, 2024
A research team led by Professor Song Si-young of orthopedic surgery at Hallym University's Dongtan Sacred Heart Hospital recently announced the results of a study that analyzed biomarkers for severe knee arthritis requiring artificial joint replacement, opening the possibility of developing new treatments.
The study, titled 'Identification of plasma and urine in severe knee arthritis: Identification of plasma and primary inflammatory biomarkers (Identification of plasma and primary inflammatory markers: Relations with synovial fluid markers)', was published in the latest issue of 'Knee Surgery & Related Research (IF: 4.1)'.
The research team analyzed cytokines in plasma and urine associated with inflammatory responses from 40 patients who underwent artificial joint total replacement or partial replacement due to severe knee arthritis. In addition, the correlation between these samples and cytokines in synovial fluid, where secretion increases in the presence of arthritis, was analyzed.
As a result, the levels of 19 cytokines in plasma and urine were significantly increased, and correlations with synovial cytokines were observed, confirming their potential as biomarkers for the development of treatment strategies for severe knee arthritis.
Professor Song Si-young "This biomarker analysis study of severe knee arthritis is expected to contribute to the development of treatment strategies for diagnosis, prediction of disease progression, observation of treatment response, and prediction of drug reactivity.", he explained. This study was conducted as a re-leap task for the Korea Research Foundation.
Professor Song Si-young has various clinical experiences in knee artificial joint surgery and artificial joint reoperation, and has published more than 40 SCI (E)-class papers on artificial joint and knee treatment over the past decade.
The study, titled 'Identification of plasma and urine in severe knee arthritis: Identification of plasma and primary inflammatory biomarkers (Identification of plasma and primary inflammatory markers: Relations with synovial fluid markers)', was published in the latest issue of 'Knee Surgery & Related Research (IF: 4.1)'.
The research team analyzed cytokines in plasma and urine associated with inflammatory responses from 40 patients who underwent artificial joint total replacement or partial replacement due to severe knee arthritis. In addition, the correlation between these samples and cytokines in synovial fluid, where secretion increases in the presence of arthritis, was analyzed.
As a result, the levels of 19 cytokines in plasma and urine were significantly increased, and correlations with synovial cytokines were observed, confirming their potential as biomarkers for the development of treatment strategies for severe knee arthritis.
Professor Song Si-young "This biomarker analysis study of severe knee arthritis is expected to contribute to the development of treatment strategies for diagnosis, prediction of disease progression, observation of treatment response, and prediction of drug reactivity.", he explained. This study was conducted as a re-leap task for the Korea Research Foundation.
Professor Song Si-young has various clinical experiences in knee artificial joint surgery and artificial joint reoperation, and has published more than 40 SCI (E)-class papers on artificial joint and knee treatment over the past decade.
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