Eye paralysis'Central retinal artery obstruction proves efficacy in restoring vision for hyperbaric oxygen therapy
Dec 04, 2024
'Eye stroke' is a disease that causes the central arteries of the retina to block and cause rapid vision loss, leading to blindness in severe cases.
The incidence rate is very rare, 8.5 per 100,000 people, but it is an emergency disease that appears acute without early symptoms and causes rapid vision loss immediately after the onset. Standard treatments include eye massage and intraocular pressure lowering drugs, but the treatment effect is limited. Even with treatment, only 22% of patients recover their vision, and less than 10% of them show a significant level of vision recovery.
Among these, research results proving the efficacy of hyperbaric oxygen therapy for central retinal artery obstruction have been published. Hyperbaric oxygen therapy is a treatment that dissolves high-pressure oxygen into the body's blood, which is two to three times higher than atmospheric pressure, to supply high-concentration oxygen to various parts of the body.
Professor Hong In-hwan (corresponding author) and Professor Lee Jung-min (1 author) and Professor Wang Soon-ju in the Department of Emergency Medicine will conduct a comprehensive evaluation of the efficacy of hyperbaric oxygen therapy for central retinal artery occlusion using enhanced depth image optical interference tomography.
The research team analyzed 50 patients treated for central retinal artery obstruction at Hallym University Dongtan Sacred Heart Hospital from December 2015 to December 2023. Twenty-one of them took standard treatments such as eye massage and intraocular pressure lowering drugs, and the remaining 29 received standard treatments and hyperbaric oxygen therapy. Patients who received only standard treatment were unable to receive hyperbaric oxygen therapy due to renal failure and abnormalities in the ear, or refused it by themselves.
In addition, in order to determine the cause of the change in vision, the maximum correction vision and the thickness of the central retina and choroid were evaluated and analyzed for 6 months after treatment. The retina is the innermost layer of the eyeball and is composed of several cells, including photoreceptor cells. It is also associated with impaired vision after central retinal artery occlusion because the choroid membrane nourishes the retina.
Thickness measurements were made by optical coherence tomography, which examines the tomographic structure in the eyeball using laser light. It took an average of 3.6 days from the onset of central retinal artery occlusion to receiving hyperbaric oxygen therapy, and an average of 11 days of hyperbaric oxygen therapy for 2 weeks.
As a result of follow-up, the group receiving hyperbaric oxygen therapy improved their vision with consistent and meaningful figures every month.
The average correction vision (logMAR) was 2.03 at the first visit to the hospital after the onset of central retinal artery obstruction, but the correction vision was 1.55 six months after hyperbaric oxygen therapy, showing three to four levels of increased vision. This is a recovery from 'Safety Manual', which is difficult to distinguish the fingers in front of your eyes before treatment, to 0.05 levels of vision, which can read the letters in the first line of the vision table at a distance of 2m after hyperbaric oxygen therapy. However, the mean corrected visual acuity (logMAR) of the group receiving only standard treatment remained almost unchanged from 2.1 before treatment to 2.11 after treatment. No adverse events were found in all patients who received hyperbaric oxygen therapy.
In addition, in the case of retinal and choroid thickness, it can be seen that the less thickness reduction, the less loss of visual cells, and the group receiving hyperbaric oxygen therapy showed less thickness reduction than the group receiving standard treatment alone. In the hyperbaric oxygen therapy group, the thickness of the retina and choroid decreased by only 9% for 6 months, but the group receiving only standard treatment reduced the thickness by 23%. In the hyperbaric oxygen therapy group, the reduction in the thickness of the retinal layer was small because photoreceptors were preserved, and the choroid membrane was a place where many blood vessels were gathered, and the thickness reduction was small because of less ischemia.
Professor Hong In-hwan "This study confirmed the therapeutic efficacy of central retinal artery occlusion through hyperbaric oxygen therapy and confirmed the association with vision recovery through the difference in thickness between the retina and the choroid."This is the first study to analyze the effects of central retinal artery occlusion treatment through hyperbaric oxygen therapy on anatomical changes and structures through analysis of the thickness of the retina and choroid, and the first study to compare and analyze visual acuity changes for 6 months after hyperbaric oxygen therapy."
Professor Hong added that `high pressure oxygen therapy helps restore vision by allowing 100% oxygen to be inhaled at high atmospheric pressure and allowing blood vessels to expand and reopen when arteries to the retina are blocked due to central retinal artery obstruction.'
The paper was recently published in the SCIE-level international journal 'Scientific Reports'.
The incidence rate is very rare, 8.5 per 100,000 people, but it is an emergency disease that appears acute without early symptoms and causes rapid vision loss immediately after the onset. Standard treatments include eye massage and intraocular pressure lowering drugs, but the treatment effect is limited. Even with treatment, only 22% of patients recover their vision, and less than 10% of them show a significant level of vision recovery.
Among these, research results proving the efficacy of hyperbaric oxygen therapy for central retinal artery obstruction have been published. Hyperbaric oxygen therapy is a treatment that dissolves high-pressure oxygen into the body's blood, which is two to three times higher than atmospheric pressure, to supply high-concentration oxygen to various parts of the body.
Professor Hong In-hwan (corresponding author) and Professor Lee Jung-min (1 author) and Professor Wang Soon-ju in the Department of Emergency Medicine will conduct a comprehensive evaluation of the efficacy of hyperbaric oxygen therapy for central retinal artery occlusion using enhanced depth image optical interference tomography.
The research team analyzed 50 patients treated for central retinal artery obstruction at Hallym University Dongtan Sacred Heart Hospital from December 2015 to December 2023. Twenty-one of them took standard treatments such as eye massage and intraocular pressure lowering drugs, and the remaining 29 received standard treatments and hyperbaric oxygen therapy. Patients who received only standard treatment were unable to receive hyperbaric oxygen therapy due to renal failure and abnormalities in the ear, or refused it by themselves.
In addition, in order to determine the cause of the change in vision, the maximum correction vision and the thickness of the central retina and choroid were evaluated and analyzed for 6 months after treatment. The retina is the innermost layer of the eyeball and is composed of several cells, including photoreceptor cells. It is also associated with impaired vision after central retinal artery occlusion because the choroid membrane nourishes the retina.
Thickness measurements were made by optical coherence tomography, which examines the tomographic structure in the eyeball using laser light. It took an average of 3.6 days from the onset of central retinal artery occlusion to receiving hyperbaric oxygen therapy, and an average of 11 days of hyperbaric oxygen therapy for 2 weeks.
As a result of follow-up, the group receiving hyperbaric oxygen therapy improved their vision with consistent and meaningful figures every month.
The average correction vision (logMAR) was 2.03 at the first visit to the hospital after the onset of central retinal artery obstruction, but the correction vision was 1.55 six months after hyperbaric oxygen therapy, showing three to four levels of increased vision. This is a recovery from 'Safety Manual', which is difficult to distinguish the fingers in front of your eyes before treatment, to 0.05 levels of vision, which can read the letters in the first line of the vision table at a distance of 2m after hyperbaric oxygen therapy. However, the mean corrected visual acuity (logMAR) of the group receiving only standard treatment remained almost unchanged from 2.1 before treatment to 2.11 after treatment. No adverse events were found in all patients who received hyperbaric oxygen therapy.
In addition, in the case of retinal and choroid thickness, it can be seen that the less thickness reduction, the less loss of visual cells, and the group receiving hyperbaric oxygen therapy showed less thickness reduction than the group receiving standard treatment alone. In the hyperbaric oxygen therapy group, the thickness of the retina and choroid decreased by only 9% for 6 months, but the group receiving only standard treatment reduced the thickness by 23%. In the hyperbaric oxygen therapy group, the reduction in the thickness of the retinal layer was small because photoreceptors were preserved, and the choroid membrane was a place where many blood vessels were gathered, and the thickness reduction was small because of less ischemia.
Professor Hong In-hwan "This study confirmed the therapeutic efficacy of central retinal artery occlusion through hyperbaric oxygen therapy and confirmed the association with vision recovery through the difference in thickness between the retina and the choroid."This is the first study to analyze the effects of central retinal artery occlusion treatment through hyperbaric oxygen therapy on anatomical changes and structures through analysis of the thickness of the retina and choroid, and the first study to compare and analyze visual acuity changes for 6 months after hyperbaric oxygen therapy."
Professor Hong added that `high pressure oxygen therapy helps restore vision by allowing 100% oxygen to be inhaled at high atmospheric pressure and allowing blood vessels to expand and reopen when arteries to the retina are blocked due to central retinal artery obstruction.'
The paper was recently published in the SCIE-level international journal 'Scientific Reports'.
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