The more fat you have in your muscles, the less effective it is to treat breast cancer
Dec 27, 2024
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A joint research team led by Kim Hyun-wook and Kim Min-hwan of Yonsei Cancer Hospital's oncology department, Hong Nam-ki of Severance Hospital's endocrine department, and Han Soo-kyung of Yonsei University's medical school research support department recently published the findings in the international journal 『Journal of Cachexia, Sarcopenia and Muscle』.
Muscular adiposis, which causes fat in muscles due to aging, is known to increase the incidence of myocardial infarction and stroke and the resulting mortality rate, but the relationship with the response of breast cancer drugs has not been revealed.
The research team confirmed the effect of myopia on hormone-positive breast cancer treatment following previous studies that revealed that abnormal metabolic control in the body negatively affects hormone-positive breast cancer treatment.
Hormone-positive breast cancer is a breast cancer with many female hormone receptors such as estrogen and progesterone in cancer cells.
The research team compared and analyzed the amount of fat in the muscle and the results of treatment (a combination of CDK4/6 inhibitors and aromatase inhibitors) for 247 hormone-positive breast cancer patients who visited Yonsei Cancer Hospital. The amount of fat in the muscle was based on abdominal CT imaging of the muscle and fat in the lumbar region of lumbar region 3.
As a result, the risk of disease progression in 83 patients with low muscle radiation density on CT due to myopathy increased by 84% compared to those with normal muscle radiation density. In particular, it was confirmed that the effectiveness of the treatment decreased in the premenopausal young patient group and the patient group without cancer metastasis to the lung or liver's internal organs. The research team analyzed that young patients before menopause may show resistance to treatment due to metabolic dysregulation if they have muscular dystrophy. In addition, it was revealed that even if there is no metastasis in the internal organs, the prognosis may be as bad as patients with metastasis if there is muscular dystrophy.
Professor Kim Hyun-wook confirmed that myopia, which shows low muscle radiation density, is a major indicator of the effectiveness of breast cancer treatment"The treatment of breast cancer patients requires efforts to improve muscle quality through nutritional management and exercise therapy as well as medication."
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