Nanoemulsion-based drug delivery system, breast prosthesis surgical complications 'Spherical Construction'Prevention
Dec 02, 2024
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Spherical construction (球型拘縮) refers to the side effects of excessive thickening and hardening of the film formed around the implant after breast implantation surgery. This can cause discomfort and pain in patients, and in severe cases, reoperation may be required, so prevention is an important task.
Professor Song Woo-jin of plastic surgery at Soon Chun Hyang University Seoul Hospital and Professor Lim Jung-kyun of the Department of Nanochemical Engineering jointly conducted a research paper 'Development of a fish oil-nanomulsion gel as a drug-delivery system to prevent spherical construction' in the online edition of the November issue of the SCI-level international academic journal Scientific reports (IF: 3.8, Top 18%, 2023 JCR). This study was conducted with the support of the National Research Foundation of Korea (NRF) and the Pan-Ministry Regenerative Medical Technology Development Project (KFRM).
The research team developed an omega-3 nanoemulsion gel (N3G) and designed it to be injectable during artificial breast prosthesis implantation so that it can continue to exhibit anti-inflammatory and anti-fibrotic effects.
A total of 30 mice were divided into a group that received no treatment after implantation of the prosthesis, a group that took omega-3 orally, and a group that applied nanoemulsion gel (N3G) to compare the thickness of the globular construction membrane.
As a result of the experiment, the nanoemulsion gel (N3G)-applied group reduced the film thickness by 21.2% compared to the non-treated group, and showed a significant reduction effect compared to the omega-3 oral dose group.
In addition to film thickness, fibrosis, collagen accumulation, and myofibroblast counts were significantly reduced, and gene expression analysis results also demonstrated inflammation and fibrosis inhibitory effects.
Professor Song Woo-jin expected that this study will contribute to improving the quality of life of breast cancer reconstruction and enlargement patients, saying, "This study presents new treatment options that can effectively prevent spherical construction.".
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