The reason for the occurrence of vascular disease due to chronic stress and cell tracking images are identified
Dec 25, 2024
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Until now, tracking imaging of fast-moving cells within arteries has been considered a technical challenge.
The convergence research team, consisting of Kim Jin-won, a professor at Korea University Guro Hospital's Cardiovascular Center, and Yoo Hong-ki, a professor of mechanical engineering at KAIST, succeeded in tracking the effects of chronic stress on arteriosclerotic inflammation in real-time in mice by synchronizing biometric images with the tremors of arteries caused by heartbeats.
According to the study, stress accelerates arteriosclerosis and increases the risk of rupture, such as significantly increasing white blood cell inflow into blood vessels in chronically stressed mice and increasing instability as inflammation in the arteriosclerotic plaque intensifies.
By examining the causal effect of stress on arteriosclerosis of blood vessels through cell tracking images, this study is expected to contribute to setting a new direction for treatment of arteriosclerosis and heart attack, which has been limited to blood vessels.
Professor Kim Jin-won said, `This result brings us one step closer to identifying the causal relationship between stress and cardiovascular disease by allowing us to observe the effects of chronic stress on cardiovascular disease in real time"Follow-up studies are underway to find new treatment strategies based on central nervous system stress to overcome cardiovascular disease " he said.
The findings were published as a cover paper in December 2024 in the renowned journal of cardiovascular science 'Arteriosclerosis, Thrombosis, and Vascular Biology', and were selected as editor-in-chief recommended research (Editor's Pick).
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