Barunseang Hospital's Platelet-rich Plasma Cell Regeneration Study Listed in SCI-Level International Journal
Jan 02, 2025
A paper jointly researched by medical staff at the joint center of Barunseang Hospital (Seo Dong-won, Yeo Jin, Jung Koo-hwang, Heo Jae-won) and the cartilage regeneration research institute (Lee Yong-soo, Lee Soo-mi, Kim Dong-hyun), a joint specialty hospital, was listed in the SCI-level international journal BioMed Research International (2024).
The topic of this paper is 'Transcriptome Analysis of Platelet-Rich Plasma-Treated Osteoarthritic Chondrocytes' after platelet-rich plasma treatment on osteoarthritis chondrocytes'.
Platelet-rich plasma (PRP) is a platelet concentrate separated from autologous blood and is known to have anti-inflammatory and cell regeneration effects, helping to heal damaged tissues. Based on this, it has recently been widely used for regenerative treatment for various musculoskeletal damage and diseases such as knee, hip joint, and osteoarthritis.
In order to understand the practical effects of PRP on cartilage cells in arthritis at the gene level, this study was conducted by first inducing the inflammatory environment to cartilage cells isolated from knee cartilage tissue of arthritis patients, processing PRP, and analyzing the gene transcriptome profile through RNA sequencing (RNA-seq).
In this study, a total of 24,424 genes were analyzed, and major genes representing changes in expression were explored in nine categories closely related to chondrocyte physiological activity, among which mRNA and protein expression were reevaluated for representative genes.
As a result, it was confirmed that PRP in chondrocytes in osteoarthritis environment has an effect on various gene expression related to anti-inflammatory, cell proliferation, and cell regeneration.
Lee Yong-soo, the corresponding author of the paper, said "The cartilage regeneration research institute has been paying attention to the cell regeneration effect of platelet rich plasma (PRP) for a long time, and has been thinking about ways to incorporate it into cartilage regeneration. This study is to confirm the practical effect of PRP on chondrocytes in arthritis, and various gene expression changes related to cell regeneration were identified through gene transcriptome expression analysis, and by exploring how to control genes that cause osteoarthritis through follow-up studies, I think it is a meaningful study result because it seems to be an opportunity to take a step closer to the development of cartilage regeneration treatments," he said.
Meanwhile, the Cartilage Regeneration Research Institute at Barunseang Hospital has been steadily conducting research on cartilage regeneration since its inception. It was selected for the first private hospital in 2023 for a national project worth 1.3 billion won and was designated as an advanced regenerative medical practice institution by the Ministry of Health and Welfare, and has been recognized for its sufficient research infrastructure and research capabilities comparable to those of advanced general hospitals and university hospitals.
The topic of this paper is 'Transcriptome Analysis of Platelet-Rich Plasma-Treated Osteoarthritic Chondrocytes' after platelet-rich plasma treatment on osteoarthritis chondrocytes'.
Platelet-rich plasma (PRP) is a platelet concentrate separated from autologous blood and is known to have anti-inflammatory and cell regeneration effects, helping to heal damaged tissues. Based on this, it has recently been widely used for regenerative treatment for various musculoskeletal damage and diseases such as knee, hip joint, and osteoarthritis.
In order to understand the practical effects of PRP on cartilage cells in arthritis at the gene level, this study was conducted by first inducing the inflammatory environment to cartilage cells isolated from knee cartilage tissue of arthritis patients, processing PRP, and analyzing the gene transcriptome profile through RNA sequencing (RNA-seq).
In this study, a total of 24,424 genes were analyzed, and major genes representing changes in expression were explored in nine categories closely related to chondrocyte physiological activity, among which mRNA and protein expression were reevaluated for representative genes.
As a result, it was confirmed that PRP in chondrocytes in osteoarthritis environment has an effect on various gene expression related to anti-inflammatory, cell proliferation, and cell regeneration.
Lee Yong-soo, the corresponding author of the paper, said "The cartilage regeneration research institute has been paying attention to the cell regeneration effect of platelet rich plasma (PRP) for a long time, and has been thinking about ways to incorporate it into cartilage regeneration. This study is to confirm the practical effect of PRP on chondrocytes in arthritis, and various gene expression changes related to cell regeneration were identified through gene transcriptome expression analysis, and by exploring how to control genes that cause osteoarthritis through follow-up studies, I think it is a meaningful study result because it seems to be an opportunity to take a step closer to the development of cartilage regeneration treatments," he said.
Meanwhile, the Cartilage Regeneration Research Institute at Barunseang Hospital has been steadily conducting research on cartilage regeneration since its inception. It was selected for the first private hospital in 2023 for a national project worth 1.3 billion won and was designated as an advanced regenerative medical practice institution by the Ministry of Health and Welfare, and has been recognized for its sufficient research infrastructure and research capabilities comparable to those of advanced general hospitals and university hospitals.
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This article was translated by Naver AI translator.
