If you had chemotherapy before breast cancer surgery, pay attention to this
Jan 15, 2025
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The research team conducted a study of 978 breast cancer patients who underwent axillary lymph node resection after prior chemotherapy at Gangnam Severance Hospital and Severance Hospital between September 2006 and February 2018.
Of the 978 subjects analyzed, 438 (44.8%) showed no lymph node involvement pathologically after prior chemotherapy, 89 (9.1%) showed micrometastasis, and 451 (46.7%) showed macrometastasis.
The research team conducted additional analysis on a group of patients who underwent axillary lymph node resection after surveillance lymph node biopsy. 296 patients (57.7%) were monitored lymph node negative, and 47 patients (9.2%) showed monitored lymph node microtransference.
The research team noted that 51.1% of patients with monitored lymph node micrometastasis showed additional metastasis, which was about three times higher than the monitored lymph node-negative patient group (P < 0.001). The monitored lymph node micrometastasis group had a larger pathological tumor size than the monitored lymph node-negative group and showed a high estrogen receptor (ER) positivity rate. Conversely, Ki-67 growth index was low.
The team also found that lymph node micrometastasis found after prior chemotherapy had no decisive effect on the patient's survival without recurrence (HR, 1.02; 95% CI, 0.42-2.49; P = 0.958). However, the monitored lymph node micrometastasis patient group was significantly more likely to experience recurrence 2.23 times than the monitored lymph node-negative patient group (P = 0.023).
The research team reported that additional metastasis in the monitored lymph node microtransference group was more commonly observed in patients with less than 14% of Ki-67 protein expression when the tumor size was more than 20mm, when the hormone receptor was positive and HER2 hormone was negative.
As for the significance of the study, Professor Jeong Joon explained that "the appropriateness of the application of axillary lymph node resection in breast cancer patients who underwent prior chemotherapy was still insufficient. Through this study, it became a cornerstone for predicting the effect on prognosis by closely reporting the prognosis of lymph node micrometastasis patients after prior chemotherapy was performed.'
Professor Lee Jang-hee said, "Through this study, the patient group who underwent prior chemotherapy was able to suggest a treatment direction that seriously considers axillary lymph node resection," he said.
This paper was published in the SCI journal 'Breast Cancer Research (IF=6.1)' under the title of'Study on the implications of axillary lymph node micrometastasis in breast cancer patients who underwent prior chemotherapy'.
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This article was translated by Naver AI translator.
