Lung cancer hidden lymphatic metastasis, CT predictable
Jan 16, 2025
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Although it is such an important lymphatic metastasis, cancer cells are sometimes identified in lymphatic specimens that were resected in the operating room after a preoperative imaging test determined that there was no lymphatic metastasis. This 'hidden lymph node metastasis' is known to be identified in 5-10% of all patients undergoing surgery.
Among these, a research team at a university hospital in Korea has recently attracted attention by suggesting a way to predict hidden lymph node metastasis in lung cancer patients.
The research team consisting of Professor Dong-wook Yoon of Cardiovascular Thoracic Surgery at Chung-Ang University Hospital, Professor Dan-bi Kang of the Clinical Epidemiology Research Center at Samsung Medical Center, Professor Joo-hee Cho, Professor Kim Hong-kwan of Cardiovascular Thoracic Surgery, and Professor Ho-yeon Lee of Radiology 'Computed tomography on a model that predicts hidden lymphatic metastasis in lung cancer patients with chest CT imaging features (Computed tomography of cN0 primary non-small cell lung cancer prediction of sociopathic node metastasis)' is an official journal of the European Society of Radiology.
Professor Dong-wook Yoon's research team classified and analyzed 2042 lung cancer patients who underwent lung resection according to the specific shape, location, and shape of the tumor on chest CT imaging.
As a result of the investigation, 36% of the tumors were observed to have lymphatic metastasis when they were located in the pulmonary bronchus, and 6% of hidden lymphatic metastasis was observed when the inside of the lung cancer lesion was in the shape of a liquid or air-filled pouch.
In addition, for the remaining tumors except for the unusual shape, the ratio of 's solid' and 's ground glass opacity (a phenomenon in which a part of the lungs sand the glass surface on CT images, making it look cloudy like opaque glass).
Here, lymphatic metastasis was identified with an 18% probability in the form of a 'pure solid' tumor in which the entire nodule was opaque within the tumor and the internal lung tissue was not completely visible, and hidden lymphatic metastasis was identified with a 1% probability in the case of less than half of the solid components.
In addition, the tumor's boundary analysis was further conducted, and it was confirmed that the probability of lymphatic metastasis increased when the tumor's boundary was visible in the shape of a thorn and when it affected the surrounding lung tissue (peri-tumoral GGO).
As a result, the research team presented a scientific model for predicting the probability of lymphatic metastasis in lung cancer patients according to the location, shape, and shape of the tumor on CT scans.
Professor Dong-wook Yoon of Cardiovascular Thoracic Surgery at Chung-Ang University Hospital said, "There have not been many studies that have analyzed hidden lymphatic metastases in lung cancer patients observed in an unusual form on CT, so this study is meaningful. In particular, when a tumor is located in an organ or affects surrounding lung tissue, the probability of lymphatic metastasis is very high, so these patients need a more active diagnosis and treatment approach."
Professor Dongwook Yoon then tried to be able to use CT scans as a precise prediction tool rather than just an imaging diagnostic tool in this study"We hope this will help medical staff apply the invasive lymphatic evaluation procedure more carefully, while reducing the number of patients undergoing unnecessary procedures."," he added.
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This article was translated by Naver AI translator.
