Polyethylene glycol used in constipation pills helps relieve hangovers
Jan 16, 2025
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A team of gastroenterology professors at Soonchunhyang University Seoul Hospital (Yang Kyung-mo, a clinical lecturer in gastroenterology at Seoul St. Mary's Hospital, and Jeong Beom-sun, a professor of anatomy at Yonsei University's Wonju College of Medicine), conducted the study by dividing the group into a single intake of alcohol and a group that consumed polyethylene glycol simultaneously with alcohol.
Professor Ryu Dam's team collected blood, small intestine, and liver tissue from two groups to measure blood alcohol concentration and blood acetaldehyde concentration, and also conducted PCR tests. I also observed behavior patterns.
The measurements showed that the elevated blood alcohol concentration and blood acetaldehyde concentration in the alcohol-only intake group decreased sharply in the simultaneous alcohol and polyethylene intake group.
In addition, small intestine and liver tissue PCR also markedly decreased the expression of inflammatory cytokine-related genes, which were elevated in the alcohol-only intake group, in the polyethylene glycol co-ingestion group.
Microscopy also showed that liver and small intestine damage in the alcohol-only intake group was noticeably reduced in the alcohol-polyethylene glycol simultaneous intake group.
In the alcohol-only intake group, behavioral patterns such as deteriorated mouse gait were also observed to recover significantly in the polyethylene simultaneous intake group, proving that polyethylene glycol helps relieve hangovers.
Professor Liudam said, "The study confirmed that consuming polyethylene glycol after drinking reduces hangovers by promoting bowel movements and inhibiting residual alcohol absorption in the body's intestinal relationship." "Polyethylene glycol is also a safe and effective drug used in pediatric constipation drugs, so I hope further research will solve the social and health problems caused by hangovers."," he stressed.
In addition, co-researchers Yang Kyung-mo, a clinical instructor, and Professor Jeong Beom-sun "As a result of this study, we found a drug that actually helps relieve hangovers that occur after drinking too much, and I hope it will also help chronic drinkers recover their overall liver health." he said.
Professor Ryu Dam's team's 'Co-administration of polyethylene glycol with binge ethanol reduction in intestinal and hepatic inflammation indicators (C57BL/6J mice by dimining ethanol absorption through the clinical wall)' was published online in January 2025 in the journal 'Alcohol Clinical & Experimental Research'.
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This article was translated by Naver AI translator.
