Weight change, colon cancer risk for 10 years
Jan 15, 2025
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The study was conducted on 10,332,397 people who underwent health checkups between 2004 and 2006 and subsequent health checkups between 2014 and 2016. The team divided weight changes into five groups: less than △5% △5-20% reduction △20% reduction △5-20% increase △20% increase and compared them to controls (groups with weight changes within ±5%).
As a result, for men with body mass index (BMI) in the range of 18.5 to 30 kg/㎡, weight gain was significantly correlated with the risk of developing colorectal cancer. In particular, a 20% or more weight gain in men under the age of 40 increased the risk of colorectal cancer by 65% (HR=1.65). On the other hand, there was no clear association between weight gain and colon cancer in women, but a more than 20% weight loss in women over their 40s reduced the risk of colon cancer by 24% (HR=0.76).
On the other hand, in the underweight group with a body mass index (BMI) of less than 18.5 kg/㎡, weight loss rather increased the risk of colon cancer. A 5-20% weight loss in men has been shown to increase the risk of developing colorectal cancer. This suggests that excessively low weight maintenance may act as a risk factor for colorectal cancer.
Professor Kim Hyun-jung of the Department of Medicine at Korea University emphasized that "the study confirmed that the association between weight change and colorectal cancer incidence differs according to gender and age, and customized prevention strategies are needed considering this." In addition, it is important to prevent weight gain for men under 40 years of age, but for women over 40 years of age above normal weight, weight loss may have a positive effect on reducing the risk of colorectal cancer.'
On the other hand, the paper was recently published in the international journal 『Scientific Reports" under the title 'Age and sex differences in the relationship between weight change and colorectal cancer risk: A Nationwide cohort studies'.
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This article was translated by Naver AI translator.
