Breast cancer patients reduce skin pigmentation after radiation therapy
Feb 25, 2025
|
Recently, however, a study found that topical creams containing peptides derived from proteins (AIMP1) present in the human body are effective in alleviating such radiation dermatitis.
Professor Park Gui-young of the Department of Dermatology at Chung-Ang University Hospital, Professor Choi Jin-hwa of the Department of Radiation Oncology, and Professor Han Hye-sung of the Department of Dermatology at Chung-Ang University Kwangmyeong Hospital recently published a research paper analyzing the effectiveness and safety of a new topical cream for alleviating radiation dermatitis after breast cancer radiation therapy.
The research team evaluated the effect of alleviating the radiant dermatitis (RD)' of cream containing the peptide derived from the 'AIMP1-derived Peptide (AdP), a cell signal control protein in the body.
The research team applied AdP (AIMP1-derived Peptide)-containing cream to the right of the patient's radiation exposure site for 8 weeks in 15 breast cancer patients who received radiation therapy, and applied the same cream but not AdP to the left.
As a result, progression of radiation dermatitis was suppressed in the area where AdP-containing cream was applied, and skin changes were alleviated. In addition, the effect of reducing moisture loss and alleviating pigmentation was also confirmed along with the skin barrier protection effect.
In addition, no side effects were observed, proving that AdP-containing cream is effective in relieving radiation dermatitis.
Professor Han Hye-sung of the Department of Dermatology at Chung-Ang University Kwangmyong Hospital said "Radiation dermatitis can occur in 50-95% of all radiotherapy patients depending on radiation exposure, especially in more than 90% of breast cancer patients.", he explained.
Professor Choi Jin-hwa of the Department of Radiation Oncology at Chung-Ang University Hospital then said "Radiant dermatitis not only lowers the quality of life of patients by causing skin pigmentation, but also causes inconvenience in the treatment process, and in severe cases risks leading to complications such as infection or sepsis."
Professor Park Gui-young of the Department of Dermatology at Chung-Ang University Hospital said, "While AIMP1-derived peptides (AdP) are known to be involved in anti-inflammatory and skin regeneration, this study has proven their effectiveness in relieving radiation dermatitis and protecting the skin."The findings are expected to serve as an important foundation for suggesting more effective skin protection methods that can prevent and alleviate radiation dermatitis in patients undergoing radiation therapy in the future."," he added.
Meanwhile, the research team's research paper was published in the February issue of the SCI-E-level international journal 『Supportive Care in Cancer" (IF: 3.0).
This article was translated by Naver AI translator.
