91% of patients with recurrent cystitis complain of anxiety...If it persists, it causes depression

Mar 06, 2025

91% of patients with recurrent cystitis complain of anxiety...If it persists, it causes depression
Photo/data source = Pixabay, Korea University Guro Hospital



91.1% of patients with recurrent cystitis feel anxious, and as the number of recurrences increases, the anxiety increases, and the longer the duration of the disease, the more pronounced the association with depression.

One in two women are known to experience cystitis at least once in their lifetime, and a third suffer at least one recurrence. Sudden recurrence of cystitis can lead to decreased self-esteem or depression, so caution is needed.

A research team led by Professor Oh Mi-mi of the Department of Urology at Korea University Guro Hospital analyzed in-depth the negative effects of recurrent cystitis on patients' mental health and daily lives beyond simple physical symptoms. From April 2018 to June 2022, we conducted a study of 112 adult women with recurrent cystitis who visited Korea University Guro Hospital and focused on quantitatively assessing the effects of recurrence frequency and disease duration on anxiety (STAI-S) and depression (PHQ-9) indicators.




As a result of our study, 68.8% of all patients recorded severe anxiety (a STAI-S anxiety scale score of 46 or higher) and 22.3% recorded moderate anxiety. As the number of recurrences increased, the anxiety scale (STAI-S) score tended to increase significantly (P<0.001), and the anxiety scale score (average 60.65) of the group with four or more recurrences increased sharply than the group with three or more recurrences (average 53.07). Depression (PHQ-9) showed a relatively low level with an average of 4.12 points, but the longer the duration of the disease, the more clearly the correlation with depression was confirmed (P=0.027).

Professor Ohimi "The results of this study suggest that the repeated occurrence of recurrent cystitis causes cumulative psychological burden on patients. Recurrent cystitis is more than just a physical symptom and has a profound effect on the mental health and quality of life of patients, so it is urgent to establish a systematic prevention and management system. "These findings highlight the need to establish prevention and early intervention treatment strategies, and are expected to contribute significantly to reducing psychological pain and socioeconomic burdens caused by recurrent cystitis.", he explained.

This research paper 'Level of Anxiety Shows a Positive Correlation With the Frequency of Acute Cystis Recurrence in Women' is published in the International Neurology Journal (2024; 28(2): 156-161) and is evaluated as a meaningful achievement in the domestic and international research community.




Meanwhile, Professor Oh Mi-mi, who served as the chairperson of the Women's Cystitis Committee of the Urologastroenterological Infectious Society, is playing a leading role as a urologist in Korea by successfully introducing the 'Recurrent Cystitis Awareness Program', a global model for improving and preventing recurrent cystitis.

91% of patients with recurrent cystitis complain of anxiety...If it persists, it causes depression
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This article was translated by Naver AI translator.